Toda N, Okamura T, Shimizu I, Tatsuno Y
Cardiovasc Res. 1985 Nov;19(11):707-13. doi: 10.1093/cvr/19.11.707.
Contractile responses to 30 mmol . litre-1 K+ of helical strips of coronary arteries from human cadavers did not change within 5 h after death; however, they were suppressed 8 h after death. In coronary arteries from monkey cadavers, the K+-induced contractions did not significantly differ within the first 5 h, but were suppressed 12 h after death. On the other hand, K+-induced contractions were retained without deterioration in cerebral artery strips from human cadavers 20 to 24 h after death and those from monkey cadavers 8 to 16 h. Acetylcholine caused contractions of human coronary arteries, but caused only a relaxation of monkey coronaries which was abolished by rubbing off the endothelium. These responses were attenuated by no more than K+-induced contractions up to 12 h after death. Maximum contractions induced by noradrenaline, histamine and serotonin remained the same in human coronary arteries for 3 to 5 h after death. Similar magnitudes of contraction were elicited by noradrenaline in human cerebral arteries up to 20 h after death. It appears that the reactivity of human coronary arteries to K+ and other vasoconstrictor agents used is normally retained for at least 6 h after death and that of human cerebral arteries up to 24 h.
来自人体尸体的冠状动脉螺旋条对30 mmol·升−1 K+的收缩反应在死后5小时内没有变化；然而，在死后8小时受到抑制。在来自猴尸体的冠状动脉中，K+诱导的收缩在最初5小时内没有显著差异，但在死后12小时受到抑制。另一方面，来自人体尸体的脑动脉条在死后20至24小时以及来自猴尸体的脑动脉条在死后8至16小时，K+诱导的收缩得以保留且未恶化。乙酰胆碱可引起人体冠状动脉收缩，但仅引起猴冠状动脉舒张，而这种舒张通过擦除内皮而被消除。这些反应在死后12小时内减弱程度不超过K+诱导的收缩。去甲肾上腺素、组胺和5-羟色胺诱导的最大收缩在人体冠状动脉死后3至5小时内保持不变。去甲肾上腺素在人体脑动脉中直至死后20小时引起的收缩幅度相似。似乎人体冠状动脉对K+和其他所用血管收缩剂的反应性在死后通常至少保留6小时，而人体脑动脉的反应性则保留至24小时。
