Sun Xuemei, Gu Jiahe
Pediatric Department, Taizhou People's Hospital, Taizhou, China.
Hell J Nucl Med. 2025 May-Aug;28(2):131-136. doi: 10.1967/s002449912804. Epub 2025 Aug 4.
To analyze and compare the diagnostic value of fluorine-18-fluorodeoxyglucose (F-FDG) positron emission tomography/computed tomography (PET/CT) imaging and integrated PET/magnetic resonance imaging (MR) in pediatric tumors.
A retrospective analysis was conducted on the clinical data of 61 pediatric patients with malignant tumors admitted to our hospital from September 2022 to December 2023. All patients underwent pathological examinations as well as F-FDG PET/CT and integrated PET/MR imaging. The pathological diagnosis results were used as the gold standard. Pearson correlation analysis, Bland-Altman analysis, and t-tests were used to compare the maximum standardized uptake value (SUVmax), signal-to-noise ratio (SNR), and target-to-background ratio (T/B) between the two methods. Chi-square tests were employed to compare the diagnostic efficacy differences of each index.
Among the 61 pediatric malignant tumor patients, a total of 417 lesions were detected, of which 363 lesions showed high uptake on both PET/MR and PET/CT. Among the remaining 54 PET-negative lesions, 9 were CT-positive but MR-negative, including 6 in the lungs and 3 in the vertebrae, while 12 lesions were MR-positive but CT-negative, including 5 in the liver, 4 in the brain, and 3 in the breasts. No statistically significant difference was found in the PET positivity rate or diagnostic results between the two devices (P<0.05). Bland-Altman analysis showed that the background uptake of PET/MR images was lower than that of PET/CT, and the SNR was higher (P<0.05); the SUVmax of the lesions on PET/MR was higher than that on PET/CT (P<0.05); the T/B value of PET/MR images was higher than that of PET/CT (P<0.05). In terms of correlation, the SUVmax, SNR, and T/B values between PET/MR and PET/CT were positively correlated (r=0.919, 0.507, 0.698, P<0.05).
In the diagnosis of pediatric malignant tumors, PET/MR and PET/CT have relatively consistent lesion detection rates. PET/MR images have a higher SNR and better resolution, making them more advantageous than PET/CT for evaluating lesions in the liver, brain, and other soft tissue organs, thus warranting clinical application.
分析并比较18F-氟脱氧葡萄糖（F-FDG）正电子发射断层扫描/计算机断层扫描（PET/CT）成像与PET/磁共振成像（MR）融合成像在儿童肿瘤中的诊断价值。
回顾性分析2022年9月至2023年12月我院收治的61例儿童恶性肿瘤患者的临床资料。所有患者均接受了病理检查以及F-FDG PET/CT和PET/MR融合成像检查。以病理诊断结果作为金标准。采用Pearson相关分析、Bland-Altman分析和t检验比较两种检查方法的最大标准化摄取值（SUVmax）、信噪比（SNR）和靶本比（T/B）。采用卡方检验比较各指标的诊断效能差异。
61例儿童恶性肿瘤患者共检测到417个病灶，其中363个病灶在PET/MR和PET/CT上均表现为高摄取。其余54个PET阴性病灶中，9个为CT阳性但MR阴性，其中肺部6个，椎体3个；12个病灶为MR阳性但CT阴性，其中肝脏5个，脑4个，乳腺3个。两种设备的PET阳性率及诊断结果差异无统计学意义（P<0.05）。Bland-Altman分析显示，PET/MR图像的背景摄取低于PET/CT，SNR更高（P<0.05）；PET/MR上病灶的SUVmax高于PET/CT（P<0.05）；PET/MR图像的T/B值高于PET/CT（P<0.05）。在相关性方面，PET/MR与PET/CT之间的SUVmax、SNR和T/B值呈正相关（r=0.919、0.507、0.698，P<0.05）。
在儿童恶性肿瘤诊断中，PET/MR和PET/CT的病灶检出率相对一致。PET/MR图像具有更高的SNR和更好的分辨率，在评估肝脏、脑等软组织器官病灶方面比PET/CT更具优势，值得临床应用。
