Santi L, Civalleri D, Conte P F, Fraschini G, Sertoli M R
Chemioterapia. 1985 Oct;4(5):359-68.
The rationale of regional intra-arterial chemotherapy of metastatic liver cancer is based on the possibility of providing higher levels and longer exposure time of the tumor to drugs. The recent availability of a totally implantable portable pump (Infusaid) had greatly reduced the catheter-related complications with very good patient compliance. An extensive review of the published results in colorectal carcinoma does not allow us to reach any firm conclusion on the validity of regional treatment: many authors report high response rates and satisfactory long term control of liver disease, but impact on survival is questionable because of extrahepatic tumor progression. Prospective randomized trials comparing systemic versus regional plus systemic chemotherapy are needed. Finally, our personal experience in colorectal and breast cancer is presented.
转移性肝癌区域动脉内化疗的基本原理是基于使肿瘤能够接触到更高浓度的药物并延长药物暴露时间的可能性。最近完全植入式便携式泵（Infusaid）的出现极大地减少了与导管相关的并发症，且患者依从性良好。对已发表的关于结直肠癌治疗结果的广泛综述，使我们无法就区域治疗的有效性得出任何确凿结论：许多作者报告了高缓解率和对肝病令人满意的长期控制，但由于肝外肿瘤进展，其对生存率的影响存在疑问。需要进行比较全身化疗与区域加全身化疗的前瞻性随机试验。最后，介绍了我们在结直肠癌和乳腺癌方面的个人经验。
