中国新冠病毒感染与内脏反位发生率的相关性研究。
Correlational study between SARS-CoV-2 infection and incidence of situs inversus in China.
作者信息
Guo Zhenglong, Wang Ruili, Yang Wenke, Chen Xin, Hao Bingtao, Liao Shixiu
机构信息
Henan Provincial Key Laboratory of Genetic Diseases and Functional Genomics, Medical Genetics Institute of Henan Province, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, No. 7 Weiwu Road, Zhengzhou City, Henan Province, China.
NHC Key Laboratory of Birth Defects Prevention, Henan Key Laboratory of Population Defects Prevention, Zhengzhou, China.
出版信息
Orphanet J Rare Dis. 2025 Aug 3;20(1):396. doi: 10.1186/s13023-025-03944-5.
Wang and colleagues linked SARS-CoV-2 infection during early pregnancy to situs inversus, a rare developmental anomaly of organ placement. However, the absence of genetic testing data raises concerns regarding the reliability of their conclusions, particularly since a similar association was not observed in Scandinavian countries. In this study, we summarize the cases of situs inversus diagnosed during the COVID-19 pandemic in Henan, China, which indicates a significant increase in the incidence of this condition. Among the 34 cases examined, 24 did not reveal any potential pathogenic variants through genetic testing. Our findings suggest a correlation between SARS-CoV-2 infection and the development of situs inversus.
王及其同事将妊娠早期的新型冠状病毒感染与内脏反位联系起来，内脏反位是一种罕见的器官位置发育异常。然而，缺乏基因检测数据引发了对其结论可靠性的担忧，特别是因为在斯堪的纳维亚国家未观察到类似关联。在本研究中，我们总结了中国河南在新冠疫情期间诊断出的内脏反位病例，这表明这种情况的发病率显著增加。在所检查的34例病例中，24例通过基因检测未发现任何潜在的致病变异。我们的研究结果表明新型冠状病毒感染与内脏反位的发生之间存在关联。
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