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[慢性游走性红斑和莱姆病引发的病因学及流行病学问题。关于雷恩地区医院中心的4例病例]

[Etiologic and epidemiologic questions posed by erythema chronicum migrans and Lyme disease. Apropos of 4 cases at the Regional Hospital Center, Rennes].

作者信息

Doby J M, Chastel C, Couatarmanac'h A, Cousanca C, Chevrant-Breton J, Martin A, Legay B, Guiguen C

出版信息

Bull Soc Pathol Exot Filiales. 1985;78(4):512-25.

PMID:4075471
Abstract

The authors give 4 observations, made in Rennes (France), of 3 cases contracted in France and 1 in Canada, cases they think to be related, for 3 at least, to the infectious entity described by American authors under the name of Lyme disease. If 1 of these cases was limited to an erythema chronicum migrans, the 3 others showed a beginning evolution towards a classical Lyme disease. In 2 of these 3 last cases, the infection was perhaps cut short by a quickly applied therapy by antibiotics. They discuss the different hypotheses about the negative Borrelia serologic reactions in 3 of the 4 cases. A possible arboviral aetiology is evocked. In only one of the 4 cases, a tick-bite can be asserted, the role in the the transmission of this kind of arthropods being strictly excluded in 2 of the 3 other cases (transmission likely by a mosquito and by a biting fly (tabanid?)). The authors put the question of the possibility of transmission, for erythema chronicum migrans and Lyme disease, by arthropods other than ticks.

摘要

作者报告了在法国雷恩的4例观察病例,其中3例在法国感染,1例在加拿大感染,他们认为这些病例至少有3例与美国作者描述的名为莱姆病的感染病原体有关。如果其中1例仅表现为慢性游走性红斑,那么另外3例则开始向典型的莱姆病发展。在最后这3例中的2例中,感染可能因迅速应用抗生素治疗而得到控制。他们讨论了4例中有3例出现博氏疏螺旋体血清学阴性反应的不同假说。有人提出了可能的虫媒病毒病因。4例中只有1例可以确定有蜱叮咬,另外3例中有2例严格排除了这种节肢动物在传播中的作用(可能是通过蚊子和一种叮咬蝇(虻?)传播)。作者提出了除蜱之外的节肢动物传播慢性游走性红斑和莱姆病的可能性问题。

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