Dzutsev Amiran K, Trinchieri Giorgio
Laboratory of Integrative Cancer Immunology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
Cancer Discov. 2025 Aug 4;15(8):1540-1542. doi: 10.1158/2159-8290.CD-25-0899.
Lu and colleagues identified profound microbial heterogeneity across individual tumor nodules in multifocal hepatocellular carcinoma, revealing that specific bacterial consortia enrich in metastatic clones and drive epithelial-mesenchymal transition and immune suppression. Their study places the intratumoral microbiome alongside genomic and transcriptomic diversity as a key modulator of intrahepatic tumor evolution. See related article by Lu et al., p. 1630.
陆及其同事发现，多灶性肝细胞癌的各个肿瘤结节间存在显著的微生物异质性，这表明特定的细菌群落富集于转移克隆中，并驱动上皮-间质转化和免疫抑制。他们的研究将肿瘤内微生物群与基因组和转录组多样性一道，视为肝内肿瘤演变的关键调节因子。见陆等人的相关文章，第1630页。
