Mainard F, Massoubre B, Le Marec H, Madec Y
Clin Chim Acta. 1985 Nov 29;153(1):1-8. doi: 10.1016/0009-8981(85)90132-9.
An immunoagglutination latex test was studied in comparison with a plasma myoglobin radioimmunoassay in 103 subjects with suspected myocardial infarction. The test provided an early and reliable indication of raised plasma myoglobin (greater than 85 micrograms/l), a biochemical marker for the early phase (12 h) of myocardial infarction. The diagnostic values (sensitivity and specificity) studied over a 36 h period were the same as those for the plasma myoglobin assay. The sensitivity was similar to that of creatine kinase activity and better than that of the creatine kinase MB/creatine kinase ratio; the lower specificity was due to false-positive results in some subjects with angina. The myoglobin test, which provides rapid results, may be substituted in early diagnosis of myocardial infarction for the plasma myoglobin assay which is unsuitable for emergency analysis.
在103名疑似心肌梗死的受试者中，对免疫凝集乳胶试验与血浆肌红蛋白放射免疫测定进行了比较研究。该试验能对血浆肌红蛋白升高（大于85微克/升）提供早期且可靠的指示，血浆肌红蛋白是心肌梗死早期阶段（12小时）的一种生化标志物。在36小时期间研究的诊断价值（敏感性和特异性）与血浆肌红蛋白测定的诊断价值相同。其敏感性与肌酸激酶活性相似，优于肌酸激酶同工酶/肌酸激酶比值；特异性较低是由于一些心绞痛患者出现假阳性结果。肌红蛋白试验结果快速，在心肌梗死的早期诊断中可替代不适用于急诊分析的血浆肌红蛋白测定。
