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模仿化脓性肉芽肿的非典型斯皮茨肿瘤:一例报告及文献复习

Atypical Spitz Tumor Mimicking Pyogenic Granuloma: A Case Report and Literature Review.

作者信息

Nagasaka Yuka, Shiraishi Tomohiro, Shibayama Takahiro, Hibiya Takashi, Shibahara Junji, Takushima Akihiko

机构信息

Department of Plastic and Reconstructive Surgery, Kyorin University School of Medicine, Tokyo, Japan.

Department of Pathology, Kyorin University School of Medicine, Tokyo, Japan.

出版信息

J Plast Reconstr Surg. 2024 Oct 25;4(3):160-163. doi: 10.53045/jprs.2024-0020. eCollection 2025 Jul 27.

DOI:10.53045/jprs.2024-0020
PMID:40755477
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12310343/
Abstract

Atypical Spitz tumors are one type of the Spitzoid melanocytic lesion, characterized by one or more atypical features, and often demonstrate indeterminate biological potential. Atypical Spitz tumors pose challenges in both clinical and pathological diagnoses. Herein, we report a case of a 1-year-old Japanese girl who presented with a rapidly enlarging lesion mimicking a pyogenic granuloma. The patient was ultimately diagnosed with an atypical Spitz tumor. The challenging clinical nature and diagnostic complexity of atypical Spitz tumors underscore their significance as crucial considerations in pediatric skin tumor differential diagnosis. Consistent consideration of atypical Spitz tumors within the diagnostic framework of pediatric cutaneous neoplasms is essential for timely and accurate assessment, thereby ensuring optimal patient care.

摘要

非典型斯皮茨肿瘤是斯皮茨样黑素细胞性病变的一种类型,其特征为具有一个或多个非典型特征,并且常常表现出不确定的生物学潜能。非典型斯皮茨肿瘤在临床和病理诊断方面均带来挑战。在此,我们报告一例1岁日本女孩,其表现为一个迅速增大的病变,类似化脓性肉芽肿。该患者最终被诊断为非典型斯皮茨肿瘤。非典型斯皮茨肿瘤具有挑战性的临床特性和诊断复杂性突显了其在儿童皮肤肿瘤鉴别诊断中作为关键考量因素的重要性。在儿童皮肤肿瘤的诊断框架内持续考虑非典型斯皮茨肿瘤对于及时准确的评估至关重要,从而确保为患者提供最佳治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57e1/12310343/05d9633b46f5/jprs-04-03-0160-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57e1/12310343/934d0cf5f01f/jprs-04-03-0160-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57e1/12310343/c50ca3442736/jprs-04-03-0160-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57e1/12310343/b55c1cd9d9c4/jprs-04-03-0160-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57e1/12310343/05d9633b46f5/jprs-04-03-0160-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57e1/12310343/934d0cf5f01f/jprs-04-03-0160-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57e1/12310343/c50ca3442736/jprs-04-03-0160-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57e1/12310343/b55c1cd9d9c4/jprs-04-03-0160-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57e1/12310343/05d9633b46f5/jprs-04-03-0160-g004.jpg

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本文引用的文献

1
Topical treatment of pyogenic granulomas in a pediatric population: A single-institution retrospective review.儿童化脓性肉芽肿的局部治疗:一项单机构回顾性研究。
JAAD Int. 2022 May 7;8:7-9. doi: 10.1016/j.jdin.2022.03.014. eCollection 2022 Sep.
2
Atypical Spitz tumours: an epidemiological, clinical and dermoscopic multicentre study with 16 years of follow-up.非典型 Spitz 肿瘤:一项具有 16 年随访的流行病学、临床和皮肤镜多中心研究。
Clin Exp Dermatol. 2022 Aug;47(8):1464-1471. doi: 10.1111/ced.15123. Epub 2022 Jun 6.
3
Spitz melanocytic tumours - a review.
斯皮茨黑素细胞肿瘤——综述
Histopathology. 2022 Jan;80(1):122-134. doi: 10.1111/his.14583.
4
Topical corticosteroids for noninvasive treatment of pyogenic granulomas.局部皮质类固醇治疗化脓性肉芽肿的非侵入性治疗。
Pediatr Dermatol. 2021 Nov;38 Suppl 2:149-151. doi: 10.1111/pde.14698. Epub 2021 Jul 16.
5
Polypoid Atypical Spitz Tumor With a Fibrosclerotic Stroma, CLIP2-BRAF Fusion, and Homozygous Loss of 9p21.具有纤维硬化性间质、CLIP2-BRAF融合及9p21纯合缺失的息肉状非典型斯皮茨肿瘤
Am J Dermatopathol. 2020 Mar;42(3):204-207. doi: 10.1097/DAD.0000000000001502.
6
The utilization of spitz-related nomenclature in the histological interpretation of cutaneous melanocytic lesions by practicing pathologists: results from the M-Path study.执业病理学家在皮肤黑素细胞性病变组织学诊断中对斯皮茨相关命名法的应用:M-Path研究结果
J Cutan Pathol. 2017 Jan;44(1):5-14. doi: 10.1111/cup.12826. Epub 2016 Oct 28.
7
Clinical and dermoscopic features of atypical Spitz tumors: A multicenter, retrospective, case-control study.非典型斯皮茨瘤的临床和皮肤镜特征:一项多中心、回顾性、病例对照研究。
J Am Acad Dermatol. 2015 Nov;73(5):777-84. doi: 10.1016/j.jaad.2015.08.018.
8
Atypical Spitz Tumors: A Diagnostic Challenge.非典型斯皮茨瘤:一项诊断挑战。
Arch Pathol Lab Med. 2015 Oct;139(10):1263-70. doi: 10.5858/arpa.2015-0207-RA.
9
Atypical Spitz tumours and sentinel lymph node biopsy: a systematic review.非典型 Spitz 肿瘤与前哨淋巴结活检:系统评价。
Lancet Oncol. 2014 Apr;15(4):e178-83. doi: 10.1016/S1470-2045(13)70608-9.
10
Pseudogranulomatous Spitz nevus: a variant of Spitz nevus with heavy inflammatory infiltrate mimicking a granulomatous dermatitis.假肉芽肿性斯皮茨痣:一种斯皮茨痣的变体,伴有大量炎症浸润,类似肉芽肿性皮炎。
J Cutan Pathol. 2013 Mar;40(3):330-5. doi: 10.1111/cup.12011. Epub 2012 Sep 18.