Efficacy of Platelet-Rich Plasma Dressing Versus Normal Saline Dressing in the Management of Diabetic Foot Ulcers: A Comparative Study Conducted in a Tertiary Care Hospital in Southern Odisha.

Background and objectives Diabetic foot ulcers (DFUs) present significant challenges due to their chronicity and potential complications. This study aims to compare the efficacy of platelet-rich plasma (PRP) versus normal saline dressing (NSD) in promoting wound healing and reducing complications among diabetic patients. Materials and methods This comparative study enrolled diabetic patients with foot ulcers, randomly assigned to either PRP or NSD treatment groups. Demographic data, ulcer characteristics, and treatment outcomes were meticulously recorded and analyzed. Statistical tests, including paired and independent samples t-tests, chi-square tests, and descriptive statistics, were employed to assess differences between the groups. Results Both groups exhibited similar age distributions, with PRP showing a slightly wider range. Sex distribution was identical between the NSD and PRP groups. PRP therapy demonstrated significant wound size reduction compared to NSD, with notable improvements in ulcer healing rates and reduced rates of complications and surgical interventions. Microbiological analysis revealed comparable infection rates between groups, with PRP potentially reducing infection-related complications. Interpretation and conclusion PRP therapy appears to offer superior efficacy over NSD in promoting DFU healing, as evidenced by substantial reductions in ulcer size and lower rates of complications. This study supports PRP as a promising treatment modality for DFUs, potentially enhancing clinical outcomes and reducing healthcare burdens.