Brito Emanuella M, Bonifanti Leonardo, Patel Rajvi, Jimenez Jailene, Junco Jacqueline, Rozenfeld Irina R, Renesca Violetta, Cheema Amanpreet K
Institute for Neuro-Immune Medicine, Nova Southeastern University Dr. Kiran C. Patel College of Osteopathic Medicine, Fort Lauderdale, USA.
Department of Biological Sciences, Nova Southeastern University Halmos College of Arts and Sciences, Fort Lauderdale, USA.
Cureus. 2025 Jul 2;17(7):e87178. doi: 10.7759/cureus.87178. eCollection 2025 Jul.
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating condition marked by severe, long-lasting fatigue and exhaustion that does not improve with rest. ME/CFS is reported in individuals of all ages and various racial, socioeconomic, and ethnic groups. This condition lacks standard treatment. Nutritional supplements and dietary interventions are often used to manage symptoms, but the efficacy of these interventions remains scarce in the current literature. This systematic review aims to evaluate and summarize recent evidence on nutrient supplementation and diet-based interventions in patients with ME/CFS sourced from clinical trial registries and article databases. Registries improve the quality, integrity, and transparency of clinical trials by providing a standardized platform for reporting study design and results and, thus, reducing the biases related to selective reporting practices. Systematic reviews using these registries, therefore, are an efficient pathway to acquire current medical evidence for use in clinical decision-making and the development of practice guidance in various fields. ClinicalTrials.gov, Medline, PubMed, Cochrane, and Web of Science were systematically searched for interventional studies in which patients suffering from ME/CFS supplemented or altered their diet. The results of this review showed several supplements that suggest improvement in patients' symptomatology, including nicotinamide adenine dinucleotide (NADH), coenzyme Q10 (CoQ10), wasabi, and probiotics. However, many of these registered clinical trials did not employ the U.S. National Institutes of Health (NIH)'s National Institute of Neurological Disorders and Stroke (NINDS) suggested common data elements (CDEs). These standardized outcome-measuring tools allow the generalization and true comparison of the patient-reported outcomes.
肌痛性脑脊髓炎/慢性疲劳综合征（ME/CFS）是一种使人衰弱的病症，其特征是严重、持久的疲劳和疲惫，休息后也无法改善。ME/CFS在各个年龄段以及不同种族、社会经济和民族群体的个体中都有报道。这种病症缺乏标准治疗方法。营养补充剂和饮食干预措施常被用于管理症状，但这些干预措施的疗效在当前文献中仍然很少见。本系统评价旨在评估和总结来自临床试验注册库和文章数据库的关于ME/CFS患者营养补充和基于饮食的干预措施的最新证据。注册库通过提供一个用于报告研究设计和结果的标准化平台，提高了临床试验的质量、完整性和透明度，从而减少了与选择性报告做法相关的偏差。因此，使用这些注册库进行系统评价是获取当前医学证据以用于临床决策和制定各领域实践指南的有效途径。我们系统检索了ClinicalTrials.gov、Medline、PubMed、Cochrane和Web of Science，以查找ME/CFS患者补充或改变饮食的干预性研究。本评价结果显示，有几种补充剂表明可改善患者症状，包括烟酰胺腺嘌呤二核苷酸（NADH）、辅酶Q10（CoQ10）、山葵和益生菌。然而，许多这些注册临床试验并未采用美国国立卫生研究院（NIH）下属国立神经疾病和中风研究所（NINDS）建议的通用数据元素（CDE）。这些标准化的结果测量工具能够对患者报告的结果进行归纳总结和真正的比较。
