Li Wenxian, Tang Hongxia, Tong Xiaowei, Zhao Yifan, Li Shien
Department of Endocrinology, The First Hospital of Zhangjiakou, Zhangjiakou, Hebei, People's Republic of China.
Diabetes Metab Syndr Obes. 2025 Jul 29;18:2597-2609. doi: 10.2147/DMSO.S528506. eCollection 2025.
The neutrophil/high-density lipoprotein cholesterol ratio (NHR) has been identified as a combined indicator of inflammatory cells and lipid metabolism. The objective of this study was to investigate the relationship between the NHR and metabolic dysfunction-associated steatotic liver disease (MASLD) in patients with type 2 diabetes mellitus (T2DM).
This cross-sectional study selected patients with T2DM who were admitted to the Department of Endocrinology at the First Hospital of Zhangjiakou City. Liver ultrasound was performed on all patients to determine the presence or absence of MASLD, and NHR values were calculated. The patients were grouped according to the median NHR, and a difference analysis was performed to compare the differences in clinical information between groups.Logistic regression was used to assess independent influences of MASLD, and subgroup analyses were performed. The final stage of this project involved construction of a novel predictive model for MASLD, derived from the screened influential factors, alongside an evaluation of its predictive value using the receiver operating characteristic.
A total of 621 patients with T2DM were included in this study according to the inclusion and exclusion criteria. Logistic regression analyses showed a significant negative correlation between NHR and MASLD, and this correlation was particularly significant in men and in patients not using GLP-1A. In addition, restricted cubic spline curve (RCS) plots showed a nonlinear correlation between NHR and MASLD. The area under the curve (AUC) of the novel prediction model constructed on the basis of NHR reached 0.78 (95% CI 0.75-0.82), which can be used to predict the onset of MASLD, and is effective in clinical applications.
NHR is significantly correlated with MASLD, and NHR has the potential to be an early detection and intervention indicator for screening T2DM patients for MASLD.
中性粒细胞/高密度脂蛋白胆固醇比值（NHR）已被确定为炎症细胞和脂质代谢的综合指标。本研究的目的是探讨2型糖尿病（T2DM）患者中NHR与代谢功能障碍相关脂肪性肝病（MASLD）之间的关系。
本横断面研究选取了张家口市第一医院内分泌科收治的T2DM患者。对所有患者进行肝脏超声检查以确定是否存在MASLD，并计算NHR值。根据NHR中位数对患者进行分组，并进行差异分析以比较各组之间临床信息的差异。采用逻辑回归评估MASLD的独立影响因素，并进行亚组分析。该项目的最后阶段涉及构建一个基于筛选出的影响因素的新型MASLD预测模型，并使用受试者工作特征曲线评估其预测价值。
根据纳入和排除标准，本研究共纳入621例T2DM患者。逻辑回归分析显示NHR与MASLD之间存在显著负相关，且这种相关性在男性和未使用GLP-1A的患者中尤为显著。此外，限制性立方样条曲线（RCS）图显示NHR与MASLD之间存在非线性相关性。基于NHR构建的新型预测模型的曲线下面积（AUC）达到0.78（95%CI 0.75-0.82），可用于预测MASLD的发病，在临床应用中有效。
NHR与MASLD显著相关，NHR有可能成为筛查T2DM患者MASLD的早期检测和干预指标。
