Feng Qianying, Chen Fengxia, Liu Rui, Li Dan, Feng Huigen, Yang Junzheng
Nursing School, North Henan Medical University, Xinxiang, 453003, China.
Guangdong Nephrotic Drug Engineering Technology Research Center, Institute of Consun Co. for Chinese Medicine in Kidney Diseases, Guangzhou, 510530, China.
Regen Ther. 2025 Jul 26;30:439-445. doi: 10.1016/j.reth.2025.07.006. eCollection 2025 Dec.
Alzheimer's disease (AD) is a type of degenerative disease that primarily affects in the central nervous system of elderly or pre-elderly individuals. The symptoms of Alzheimer's disease include memory impairment, aphasia, loss of function, dementia, and impairment of visual spatial ability, which in turn affects the physical health of patients. Mesenchymal stem cell therapy is a branch of regenerative medicine that primarily utilizes stem cells or their derivatives to stimulate the body's own healing process and repair damaged, diseased, or injured tissues. Its utilization in the treatment of autoimmune diseases and neurological disorders has been extensively documented. This review summarizes the preclinical and clinical applications of mesenchymal stem cells in AD, their underlying mechanisms and the application limitations of their application and potential solutions. It is hoped that researchers in this field will find it a useful foundation for further study of mesenchymal stem cell therapy.
阿尔茨海默病（AD）是一种退行性疾病，主要影响老年人或接近老年个体的中枢神经系统。阿尔茨海默病的症状包括记忆障碍、失语、功能丧失、痴呆以及视觉空间能力受损，进而影响患者的身体健康。间充质干细胞疗法是再生医学的一个分支，主要利用干细胞或其衍生物来刺激机体自身的愈合过程，并修复受损、患病或受伤的组织。其在自身免疫性疾病和神经疾病治疗中的应用已有大量文献记载。本综述总结了间充质干细胞在AD中的临床前和临床应用、其潜在机制以及应用局限性和可能的解决方案。希望该领域的研究人员能将其作为进一步研究间充质干细胞疗法的有用基础。
