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儿童原发性肺转移的低分化侵袭性骶骨脊索瘤——病例报告

Poorly Differentiated Aggressive Sacral Chordoma With Upfront Lung Metastases in a Child-A Case Report.

作者信息

Dokania Shubham, Nanda Sambit S, Patne Shashikant C U, Azad Shabana, Sisodiya Rahul, Mukherji Ashutosh

机构信息

Department of Radiation Oncology Homi Bhabha Cancer Hospital, Homi Bhabha National Institue Varanasi India.

Department of Oncopathology Homi Bhabha Cancer Hospital, Homi Bhabha National Institue Varanasi India.

出版信息

Clin Case Rep. 2025 Aug 1;13(8):e70738. doi: 10.1002/ccr3.70738. eCollection 2025 Aug.

DOI:10.1002/ccr3.70738
PMID:40756092
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12317115/
Abstract

Poorly differentiated chordoma is a very unique type of chordoma with a particularly aggressive clinical course and high metastatic potential. It almost exclusively affects children and young adolescents. Unlike conventional chordomas, poorly differentiated chordomas cannot be well controlled with surgery and radiation therapy. Systemic agents are required for the treatment of this aggressive malignancy.

摘要

低分化脊索瘤是一种非常独特的脊索瘤类型，具有特别侵袭性的临床病程和高转移潜能。它几乎只影响儿童和青少年。与传统脊索瘤不同，低分化脊索瘤无法通过手术和放射治疗得到良好控制。治疗这种侵袭性恶性肿瘤需要全身用药。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/afcf/12317115/59a6cfbf2150/CCR3-13-e70738-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/afcf/12317115/8cecac1c7861/CCR3-13-e70738-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/afcf/12317115/24618e901bb6/CCR3-13-e70738-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/afcf/12317115/59a6cfbf2150/CCR3-13-e70738-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/afcf/12317115/8cecac1c7861/CCR3-13-e70738-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/afcf/12317115/24618e901bb6/CCR3-13-e70738-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/afcf/12317115/59a6cfbf2150/CCR3-13-e70738-g001.jpg

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本文引用的文献

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Front Surg. 2024 May 30;11:1375567. doi: 10.3389/fsurg.2024.1375567. eCollection 2024.
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Proton versus photon adjuvant radiotherapy: a multicenter comparative evaluation of recurrence following spinal chordoma resection.质子与光子辅助放疗：对比分析脊索瘤切除术后复发的多中心研究。
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Radiotherapy for Mobile Spine and Sacral Chordoma: A Critical Review and Practical Guide from the Spine Tumor Academy.
可移动脊柱和骶骨脊索瘤的放射治疗：来自脊柱肿瘤学会的批判性综述与实用指南
Cancers (Basel). 2023 Apr 18;15(8):2359. doi: 10.3390/cancers15082359.
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High dose image-guided, intensity modulated radiation therapy (IG-IMRT) for chordomas of the sacrum, mobile spine and skull base: preliminary outcomes.高剂量图像引导调强放疗（IG-IMRT）治疗骶骨、活动脊柱和颅底脊索瘤：初步结果。
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Clinicopathological and Prognostic Characteristics in Dedifferentiated/Poorly Differentiated Chordomas: A Pooled Analysis of Individual Patient Data From 58 Studies and Comparison With Conventional Chordomas.去分化/低分化脊索瘤的临床病理特征及预后：来自58项研究的个体患者数据汇总分析及与传统脊索瘤的比较
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