Liao Gerald Yu, Ladiges Warren
Department of Comparative Medicine, School of Medicine, University of Washington, Seattle, WA 98195, USA.
Aging Pathobiol Ther. 2024;6(3):100-101. doi: 10.31491/apt.2024.09.147. Epub 2024 Dec 26.
Chronic neurodegenerative diseases pose a significant public health challenge due to their profound impact on individual autonomy and identity. Adult neurogenesis (ANG), the ongoing generation of neurons in specific brain regions, offers promising therapeutic avenues for these diseases. Despite controversies surrounding the existence and functional relevance of ANG in humans, emerging evidence suggests individual variability in ANG induction may hold the key to understanding and addressing these conditions. We advocate for a shift in research focus towards unraveling the genetic mechanisms governing ANG and understanding its functional significance in cognition. Novel models are needed to move this concept forward. The heterogeneous domestic house cricket () has practical advantages and potential for rapid insights into neurogenesis. This model, coupled with advanced methodologies such as immunohistochemistry and RNA sequencing, can provide a detailed understanding of ANG and its therapeutic potential. Ultimately, embracing innovative models and holistic approaches to ANG research will help unlock new strategies for treating and preventing chronic neurodegenerative diseases.
慢性神经退行性疾病对个人自主性和身份认同产生深远影响，给公共卫生带来了重大挑战。成体神经发生（ANG），即特定脑区持续产生神经元的过程，为这些疾病提供了有前景的治疗途径。尽管关于人类ANG的存在及其功能相关性存在争议，但新出现的证据表明，ANG诱导的个体差异可能是理解和应对这些疾病的关键。我们主张将研究重点转向揭示调控ANG的遗传机制，并了解其在认知中的功能意义。需要新的模型来推动这一概念的发展。异质的家蟋蟀具有实际优势，有可能快速洞察神经发生。该模型与免疫组织化学和RNA测序等先进方法相结合，可以详细了解ANG及其治疗潜力。最终，采用创新模型和整体方法进行ANG研究将有助于解锁治疗和预防慢性神经退行性疾病的新策略。
