Chen Ying-Ju, Er Tze-Kiong
Division of Laboratory Medicine, Asia University Hospital, Asia University, Taichung, Taiwan.
Department of Nursing, Asia University, Taichung, Taiwan.
IJID Reg. 2025 Jul 10;16:100702. doi: 10.1016/j.ijregi.2025.100702. eCollection 2025 Sep.
Methicillin-resistant (MRSA) remains a significant public health concern, associated with high morbidity, increased healthcare costs, and limited treatment options due to antimicrobial resistance. Monitoring MRSA trends is essential to support effective infection prevention and control strategies in healthcare settings.
This retrospective study analyzed clinical specimens tested for between January 2022 and December 2024 at a regional hospital in central Taiwan. Monthly and annual MRSA prevalence rates were calculated as the proportion of MRSA-positive isolates. A chi-square test of independence was used to assess the statistical significance of prevalence differences across years.
A total of 1,824 isolates were identified during the study period, including 287 MRSA cases in 2022 (48.9%), 281 in 2023 (42.3%), and 278 in 2024 (48.5%). The chi-square test revealed a statistically significant difference in annual MRSA prevalence (χ² = 6.94, = 0.031), indicating a meaningful variation in resistance patterns across years.
MRSA prevalence fluctuated over the 3-year period, with a temporary decline in 2023 followed by a rebound in 2024. These findings underscore the importance of continuous surveillance and adaptable infection control strategies to address evolving antimicrobial resistance in hospital environments.
耐甲氧西林金黄色葡萄球菌（MRSA）仍然是一个重大的公共卫生问题，与高发病率、医疗成本增加以及由于抗菌药物耐药性导致的治疗选择有限相关。监测MRSA趋势对于支持医疗机构有效的感染预防和控制策略至关重要。
这项回顾性研究分析了2022年1月至2024年12月期间台湾中部一家地区医院检测的临床标本。每月和每年的MRSA患病率计算为MRSA阳性分离株的比例。使用独立性卡方检验来评估各年份患病率差异的统计学意义。
在研究期间共鉴定出1824株分离株，包括2022年的287例MRSA病例（48.9%）、2023年的281例（42.3%）和2024年的278例（48.5%）。卡方检验显示年度MRSA患病率存在统计学显著差异（χ² = 6.94，P = 0.031），表明各年份耐药模式存在有意义的变化。
MRSA患病率在3年期间波动，2023年暂时下降，随后在2024年反弹。这些发现强调了持续监测和适应性感染控制策略对于应对医院环境中不断演变的抗菌药物耐药性的重要性。
