Department of Clinical Pharmacy, School of Pharmaceutical Sciences, Universiti Sains Malaysia, Malaysia; Ibrahim Badamasi Babangida Specialist Hospital, Minna, Nigeria.
Department of Clinical Pharmacy, School of Pharmaceutical Sciences, Universiti Sains Malaysia, Malaysia.
J Infect Public Health. 2018 Nov-Dec;11(6):763-770. doi: 10.1016/j.jiph.2018.05.013. Epub 2018 Jun 19.
Evidence to demonstrate the prevalence and trend of Methicillin Resistant Staphylococcus aureus (MRSA) infection in Nigeria is scarce. This review evaluates the prevalence, trend and antimicrobial susceptibility of clinical MRSA isolates reported in published studies.
Electronic search (PubMed, Scopus and Google scholar) was conducted using the following search terms: "MRSA OR Methicillin Resistant Staphylococcus aureus AND Nigeria." Reference list of selected studies was scanned to identify more studies. Studies published between 2007 and 2017 that tested at least 30 non-duplicate S. aureus isolates were selected. An independent reviewer extracted data from the studies using a standardized form.
Twelve studies were included in this review. Overall, prevalence of MRSA infection increased from 18.3% (2009) to 42.3% (2013). The prevalence of MRSA infection was less than 50% in all the regions during the period under review. There was a decline in the prevalence of MRSA infection in the North-East (from 12.5% to 8.0%) between 2007 and 2012, and an increase in the South-West (from 20.2% to 47.4%) between 2006 and 2010. Wound, blood and urine specimens had the highest proportion of MRSA isolates. Non-susceptibility of MRSA strains to cotrimoxazole and tetracycline was greater than 85%.
Prevalence of MRSA infection in Nigeria is rising, albeit regional variations. Non-susceptibility to commonly prescribed, orally available and inexpensive antibiotics was high. Antimicrobial resistance surveillance system, infection control, and antimicrobial stewardship interventions are recommended.
在尼日利亚，有关耐甲氧西林金黄色葡萄球菌（MRSA）感染的流行率和趋势的证据很少。本综述评估了已发表研究中报告的临床 MRSA 分离株的流行率、趋势和抗菌药物敏感性。
使用以下搜索词在电子数据库（PubMed、Scopus 和 Google Scholar）中进行了电子检索：“MRSA 或耐甲氧西林金黄色葡萄球菌和尼日利亚”。扫描选定研究的参考文献列表以确定更多的研究。选择了发表于 2007 年至 2017 年期间、至少测试了 30 个非重复的金黄色葡萄球菌分离株的研究。一名独立审查员使用标准化表格从研究中提取数据。
本综述共纳入 12 项研究。总体而言，MRSA 感染的流行率从 2009 年的 18.3%上升到 2013 年的 42.3%。在整个研究期间，所有地区的 MRSA 感染流行率均低于 50%。2007 年至 2012 年间，东北地区的 MRSA 感染流行率从 12.5%下降到 8.0%，而 2006 年至 2010 年间，西南地区的流行率从 20.2%上升到 47.4%。伤口、血液和尿液标本中 MRSA 分离株的比例最高。MRSA 菌株对复方磺胺甲噁唑和四环素的耐药率大于 85%。
尼日利亚的 MRSA 感染流行率正在上升，尽管存在地区差异。对常用的、口服的、廉价的抗生素的耐药性很高。建议建立抗菌药物耐药性监测系统、感染控制和抗菌药物管理干预措施。
