Taha Mohamad, Faiz Saadia A, Jani Pushan, Liu Jing, Ali Yasir D, Amjad Mohammad Asim
College of Medicine, Texas A&M University Health Science Center, Bryan, TX, USA.
Department of Pulmonary Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
SAGE Open Med Case Rep. 2025 Jul 31;13:2050313X251364130. doi: 10.1177/2050313X251364130. eCollection 2025.
Giant cell tumors of the bone are typically benign, locally aggressive lesions that rarely metastasize. In this report, we describe the case of a 48-year-old woman presenting with a giant cell tumor of the bone of the hip joint, which demonstrated aggressive histological features and recurrent behavior. The patient developed multiple unresectable pulmonary metastases despite several wide local excisions. Although pulmonary metastases from giant cell tumors of the bone are usually associated with a relatively favorable prognosis, guidelines for the optimal treatment of metastatic giant cell tumors of the bone remain limited. This case highlights the unpredictable nature of giant cell tumors of the bone and emphasizes the need for alternative treatment options in those with resistance to traditional therapies.
骨巨细胞瘤通常为良性、具有局部侵袭性的病变，很少发生转移。在本报告中，我们描述了一名48岁女性的病例，该患者患有髋关节骨巨细胞瘤，表现出侵袭性的组织学特征和复发行为。尽管进行了多次广泛的局部切除，患者仍出现了多处不可切除的肺转移。虽然骨巨细胞瘤的肺转移通常预后相对较好，但针对转移性骨巨细胞瘤的最佳治疗指南仍然有限。该病例突出了骨巨细胞瘤的不可预测性，并强调了对传统治疗耐药的患者需要 alternative treatment options。 （最后一句中“alternative treatment options”未明确对应准确中文，可结合上下文理解为“其他治疗选择”等意思 ）
