Marset Xavier, Montilla-Verdú Salvador, Rico Elio, Guijarro Néstor
Institute of Electrochemistry, Universidad de Alicante, Apdo. 99, 3080 Alacant, Spain.
ACS Electrochem. 2024 Nov 27;1(1):3-19. doi: 10.1021/acselectrochem.4c00129. eCollection 2025 Jan 2.
Organic electrosynthesis has emerged as a unique platform for chemical manufacturing owing to not only the use of electricity as a green reagent but also, especially, to its distinct reactivity. While conventional solvents are sought to remain inert and solely provide a liquid environment for the electrochemical process to occur, fluorinated alcohol solvents have been shown to redefine this concept. In fact, the singular properties of these solvents allow them to actively interact with the substrates and reaction intermediates driving dramatic changes in the chemo- and regioselectivity as well as on the reaction yields. Given the rapid permeation of these solvents in the burgeoning field of electro-organic synthesis, this mini-review strives to provide a concise but up-to-date critical revision for the growing community of scientists working at the interface of synthetic chemistry and electrochemistry. Here, the main electrosynthetic transformations where they have been exploited besides their key role in activating certain reaction pathways will be highlighted. Finally, a forward-looking perspective on the more practical evolution and implementation of these systems will be discussed.
有机电合成已成为化学制造的一个独特平台，这不仅是因为使用电力作为绿色试剂，更特别的是由于其独特的反应活性。虽然传统溶剂旨在保持惰性，只为电化学过程提供一个发生反应的液体环境，但含氟醇溶剂已被证明重新定义了这一概念。事实上，这些溶剂的独特性质使其能够与底物和反应中间体发生积极相互作用，从而显著改变化学选择性和区域选择性以及反应产率。鉴于这些溶剂在新兴的有机电合成领域迅速渗透，本综述旨在为在合成化学和电化学交叉领域工作的不断壮大的科学家群体提供一个简洁但最新的批判性综述。在此，除了它们在激活某些反应途径中的关键作用外，还将重点介绍利用这些溶剂进行的主要电合成转化。最后，将讨论这些体系在更实际应用方面的发展和实施的前瞻性观点。
