Feng Hao, Wang Xin, Wang Wenjuan, Zhao Xingquan
Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
China National Clinical Research Center for Neurological Diseases, Beijing, China.
Front Neurol. 2025 Jul 18;16:1619440. doi: 10.3389/fneur.2025.1619440. eCollection 2025.
Previous studies indicate a potential link between elevated serum lipid levels and an increased risk of cerebral microbleeds (CMBs). Since multiple CMBs can elevate the risk of future intracerebral hemorrhage (ICH), it is important to explore the relationship between lipid profiles and CMBs in ICH patients. However, data on this specific correlation in ICH populations are currently limited.
This study retrospectively enrolled 223 consecutive patients from a spontaneous ICH cohort. We collected comprehensive clinical, demographic, and laboratory data, with a focus on lipid levels and the presence of CMBs. Using a multivariate logistic regression model, we investigated the association between lipid parameters and CMB occurrence.
Among the 223 patients, 111 (49.8%) had CMBs. Univariate analysis showed that individuals without lobar CMBs tended to have higher levels of serum total cholesterol (TC), low-density lipoprotein (LDL), and non-high-density lipoprotein (Non-HDL). After adjusting for potential confounders, TC [odds ratio (OR), 0.989; 95% confidence interval (CI), 0.979-0.999; = 0.028] and Non-HDL (OR, 0.989; 95% CI, 0.979-1.000; = 0.043) were identified as independent predictors of lobar CMBs.
Our findings suggest an inverse correlation between TC and Non-HDL levels and the presence of lobar CMBs in ICH patients. Further prospective studies are needed to clarify the causal relationship between statin use and CMBs in ICH patients and to evaluate the prognostic significance of CMB presence and severity in statin-treated individuals.
既往研究表明血清脂质水平升高与脑微出血（CMB）风险增加之间存在潜在联系。由于多发性CMB会增加未来发生脑出血（ICH）的风险，因此探究ICH患者的血脂谱与CMB之间的关系很重要。然而，目前关于ICH人群中这种特定相关性的数据有限。
本研究回顾性纳入了来自自发性ICH队列的223例连续患者。我们收集了全面的临床、人口统计学和实验室数据，重点关注血脂水平和CMB的存在情况。使用多因素逻辑回归模型，我们研究了脂质参数与CMB发生之间的关联。
在223例患者中，111例（49.8%）有CMB。单因素分析显示，无叶型CMB的个体血清总胆固醇（TC）、低密度脂蛋白（LDL）和非高密度脂蛋白（Non-HDL）水平往往较高。在调整潜在混杂因素后，TC[比值比（OR），0.989；95%置信区间（CI），0.979-0.999；P = 0.028]和Non-HDL（OR，0.989；95%CI，0.979-1.000；P = 0.043）被确定为叶型CMB的独立预测因素。
我们的研究结果表明，ICH患者的TC和Non-HDL水平与叶型CMB的存在呈负相关。需要进一步的前瞻性研究来阐明他汀类药物使用与ICH患者CMB之间的因果关系，并评估CMB的存在和严重程度对接受他汀类药物治疗个体的预后意义。
