Huynh Minh Phuc Khanh, Vuong Lan Ngoc
Department of Infertility, Hung Vuong Hospital, Ho Chi Minh City, Vietnam.
Department of Obstetrics and Gyncecology, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam.
J Reprod Infertil. 2025 Jan-Mar;26(1):28-35. doi: 10.18502/jri.v26i1.18779.
Low serum progesterone concentration on the day of frozen embryo transfer (FET) has been associated with adverse pregnancy outcomes. Progesterone supplementation has been shown to improve the outcomes in these cycles. The purpose of the current study was to investigate the prevalence, pregnancy outcomes, and factors associated with rescued FET cycles involving low serum progesterone concentrations.
A cross-sectional study was conducted on 367 FET cycles with hormonal endometrium preparation (oral estradiol+vaginal progesterone) at Hung Vuong Hospital, Vietnam, from October 2022 to February 2023. Serum progesterone concentrations were measured on the day of FET. All cycles with serum progesterone <10 were supplemented with intramuscular progesterone according to the hospital protocol, and outcomes were subsequently observed.
The prevalence of cycles with low serum progesterone concentration was 71.66% (263/367). Factors associated with low serum progesterone were female body weight (ORadj=1.04; 95%CI: 1.0006-1.07) and duration from the last progesterone dose to blood sampling (ORadj=1.11; 95%CI: 1.03-1.19). Despite being rescued with progesterone supplementation, cycles with serum progesterone <10 had significantly lower chemical (ORadj=0.52; 95%CI: 0.31-0.89), clinical (ORadj=0.54; 95%CI: 0.31-0.93) and ongoing (ORadj=0.54; 95%CI: 0.31-0.94) pregnancy rates.
A high prevalence of frozen-thawed cycles with low serum progesterone concentrations was observed in this study, which was associated with female body weight and duration from the last progesterone dose to blood sampling. Despite progesterone rescue, lower pregnancy rates were detected in cycles with serum progesterone <10 .
冻融胚胎移植（FET）当天血清孕酮浓度低与不良妊娠结局相关。补充孕酮已被证明可改善这些周期的结局。本研究的目的是调查涉及血清孕酮浓度低的补救性FET周期的患病率、妊娠结局及相关因素。
2022年10月至2023年2月在越南洪王医院对367个采用激素子宫内膜准备（口服雌二醇+阴道孕酮）的FET周期进行了一项横断面研究。在FET当天测量血清孕酮浓度。所有血清孕酮<10的周期均根据医院方案补充肌肉注射孕酮，随后观察结局。
血清孕酮浓度低的周期患病率为71.66%（263/367）。与血清孕酮低相关的因素为女性体重（校正OR=1.04；95%CI：1.0006-1.07）和从最后一次孕酮给药到采血的时长（校正OR=1.11；95%CI：1.03-1.19）。尽管通过补充孕酮进行了补救，但血清孕酮<10的周期的生化妊娠率（校正OR=0.52；95%CI：0.31-0.89）、临床妊娠率（校正OR=0.54；95%CI：0.31-0.93）和持续妊娠率（校正OR=0.54；95%CI：0.31-0.94）显著较低。
本研究中观察到血清孕酮浓度低的冻融周期患病率很高，这与女性体重以及从最后一次孕酮给药到采血的时长有关。尽管进行了孕酮补救，但血清孕酮<10的周期的妊娠率较低。
