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IgA血管炎和IgA肾病的罕见表现:一例报告

An Unusual Presentation of IgA Vasculitis and IgA Nephropathy: A Case Report.

作者信息

Colantonio Mark A, Condiles Nicholas, Lim Alan P, Shawwa Khaled

机构信息

Department of Medicine, West Virginia University, Morgantown, WV, USA.

Division of Nephrology, West Virginia University, Morgantown, WV, USA.

出版信息

J Community Hosp Intern Med Perspect. 2025 Jul 3;15(4):61-65. doi: 10.55729/2000-9666.1502. eCollection 2025.

Abstract

Immunoglobulin A (IgA) nephropathy is the most common glomerulonephritis worldwide. While IgA nephropathy mainly presents with renal manifestations, systemic symptoms associated with vasculitis are uncommon. Oftentimes, creatinine is used as a serum marker for renal dysfunction; however, it may not always be sensitive, especially in patients with low muscle mass. In such cases, cystatin C may prove to be a better indicator of renal function. Here, we present a case of IgA nephropathy with a normal serum creatinine and elevated cystatin C, highlighting the utility of cystatin C in the setting of a normal creatinine and high suspicion for renal dysfunction.

摘要

免疫球蛋白A(IgA)肾病是全球最常见的肾小球肾炎。虽然IgA肾病主要表现为肾脏症状,但与血管炎相关的全身症状并不常见。通常,肌酐被用作肾功能不全的血清标志物;然而,它可能并不总是敏感的,尤其是在肌肉量低的患者中。在这种情况下,胱抑素C可能被证明是肾功能的更好指标。在此,我们报告一例血清肌酐正常但胱抑素C升高的IgA肾病病例,强调了在肌酐正常但高度怀疑肾功能不全的情况下胱抑素C的实用性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/599d/12315905/2b3e7c0567a8/jchim-15-04-061f1.jpg

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