Colantonio Mark A, Condiles Nicholas, Lim Alan P, Shawwa Khaled
Department of Medicine, West Virginia University, Morgantown, WV, USA.
Division of Nephrology, West Virginia University, Morgantown, WV, USA.
J Community Hosp Intern Med Perspect. 2025 Jul 3;15(4):61-65. doi: 10.55729/2000-9666.1502. eCollection 2025.
Immunoglobulin A (IgA) nephropathy is the most common glomerulonephritis worldwide. While IgA nephropathy mainly presents with renal manifestations, systemic symptoms associated with vasculitis are uncommon. Oftentimes, creatinine is used as a serum marker for renal dysfunction; however, it may not always be sensitive, especially in patients with low muscle mass. In such cases, cystatin C may prove to be a better indicator of renal function. Here, we present a case of IgA nephropathy with a normal serum creatinine and elevated cystatin C, highlighting the utility of cystatin C in the setting of a normal creatinine and high suspicion for renal dysfunction.
免疫球蛋白A（IgA）肾病是全球最常见的肾小球肾炎。虽然IgA肾病主要表现为肾脏症状，但与血管炎相关的全身症状并不常见。通常，肌酐被用作肾功能不全的血清标志物；然而，它可能并不总是敏感的，尤其是在肌肉量低的患者中。在这种情况下，胱抑素C可能被证明是肾功能的更好指标。在此，我们报告一例血清肌酐正常但胱抑素C升高的IgA肾病病例，强调了在肌酐正常但高度怀疑肾功能不全的情况下胱抑素C的实用性。
