Karakousis Nikolaos D, Gourgoulianis Konstantinos I, Papanas Nikolaos, Kotsiou Ourania S
Department of Respiratory Medicine, Faculty of Medicine, University of Thessaly, 41110 Larissa, Greece.
Second Department of Internal Medicine, Diabetes Centre-Diabetic Foot Clinic, Democritus University of Thrace, 68100 Alexandroupolis, Greece.
Muscles. 2024 Feb 8;3(1):48-59. doi: 10.3390/muscles3010006.
Pleural mesothelioma (PM) is a tumor related to adverse prognosis. The PM WHO classification has mainly identified three major subtypes of PM which are epithelioid, biphasic, and sarcomatoid. Sarcopenia is a medical issue related to a reduction in muscle mass and strength. It represents a major health issue globally because it is related to adverse effects such as hospitalization, increased length of stay, disability, increased morbidity and mortality and augmented health care expenditures. In this literature review, we attempted to examine the upcoming association between sarcopenia and PM. As recorded by the current literature, muscle loss in PM subjects was related to poorer survival and lower levels of activity. Subjects with PM had increased rates of pre-sarcopenia and malnutrition, while pre-sarcopenia was related to worse activity levels, and malnutrition was related to worse quality of life (QoL). Both tumor volume and sarcopenia were related to long-term mortality in surgically treated PM subjects, while sarcopenia was present both pre-operatively and post-operatively in these subjects. In addition, post-operative sarcopenic subjects showed a decreased 3-year overall survival (OS) in comparison with those who did not have sarcopenia, while pre-operative sarcopenia was importantly related to an increased rate of post-operative adverse outcomes. More studies are needed to validate these claims.
胸膜间皮瘤（PM）是一种预后不良的肿瘤。世界卫生组织（WHO）对PM的分类主要确定了三种主要亚型，即上皮样、双向性和肉瘤样。肌肉减少症是一个与肌肉质量和力量下降相关的医学问题。它是全球一个主要的健康问题，因为它与诸如住院、住院时间延长、残疾、发病率和死亡率增加以及医疗保健支出增加等不良影响有关。在这篇文献综述中，我们试图研究肌肉减少症与PM之间即将出现的关联。正如当前文献所记录的，PM患者的肌肉流失与较差的生存率和较低的活动水平有关。PM患者的肌肉减少症前期和营养不良发生率增加，而肌肉减少症前期与较差的活动水平有关，营养不良与较差的生活质量（QoL）有关。肿瘤体积和肌肉减少症都与接受手术治疗的PM患者的长期死亡率有关，而这些患者术前和术后都存在肌肉减少症。此外，与没有肌肉减少症的患者相比，术后发生肌肉减少症的患者3年总生存率（OS）降低，而术前肌肉减少症与术后不良结局发生率增加密切相关。需要更多的研究来证实这些说法。
