Alisik Tugba, Reis Altan Yagmur Cagla, Alisik Murat, Nacir Baris
Department of Physical Medicine and Rehabilitation, Bolu Abant İzzet Baysal University, Bolu, Türkiye.
Department of Physical Medicine and Rehabilitation, Halil Şıvgın Çubuk State Hospital, Ankara, Türkiye.
Arch Rheumatol. 2025 Jun 23;40(2):157-163. doi: 10.5152/ArchRheumatol.2025.11014.
Background/Aims: Catestatin (CST) is a bioactive peptide with wellestablished cardiovascular roles, including anti-inflammatory and metabolic effects. This study aimed to compare the serum CST levels in patients with ankylosing spondylitis (AS) and healthy control subjects. Materials and Methods: This cross-sectional study included 95 patients with AS who met the Assessment of SpondyloArthritis International Society classification criteria for AS and 85 healthy individuals. Demographic, clinical, and laboratory parameters were recorded. Serum CST levels were measured by commercially available enzyme-linked immunosorbent assay kits. Results: Median serum CST levels were significantly lower in patients with AS compared to the control group (2.57 [1.74-4.58] vs 9.4 [3.55-26.6] ng/mL, P < .001). Catestatin levels were lower in the active AS group than in the inactive AS and control groups (P < .05). Significant negative correlations were found between CST and age, ankylosing spondylitis disease activity score-C-reactive protein (ASDAS-CRP), and C-reactive protein. Multiple linear regression analysis demonstrated that serum CST levels were significantly associated with the ASDAS-CRP group variable after model adjustment for sex, age, body mass index, HLA-B27 status, disease duration, and medications. Conclusion: These findings suggest that CST may play a role in the complex pathophysiology of AS. However, future multicenter longitudinal studies are necessary to further elucidate the relationship between CST and AS.
背景/目的：降钙素原（CST）是一种具有明确心血管作用的生物活性肽，包括抗炎和代谢作用。本研究旨在比较强直性脊柱炎（AS）患者和健康对照者的血清CST水平。材料与方法：这项横断面研究纳入了95例符合国际脊柱关节炎学会AS分类标准的AS患者和85名健康个体。记录人口统计学、临床和实验室参数。血清CST水平采用市售酶联免疫吸附测定试剂盒进行检测。结果：与对照组相比，AS患者的血清CST水平中位数显著降低（2.57[1.74 - 4.58]对9.4[3.55 - 26.6]ng/mL，P <.001）。活动期AS组的降钙素原水平低于非活动期AS组和对照组（P <.05）。CST与年龄、强直性脊柱炎疾病活动评分- C反应蛋白（ASDAS-CRP）和C反应蛋白之间存在显著负相关。多线性回归分析表明，在对性别、年龄、体重指数、HLA-B27状态、病程和药物进行模型调整后，血清CST水平与ASDAS-CRP组变量显著相关。结论：这些发现表明CST可能在AS复杂的病理生理过程中发挥作用。然而，未来需要多中心纵向研究来进一步阐明CST与AS之间的关系。
