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哺乳期的耳鼻咽喉科疾病——哪些药物与母乳喂养相容?

[Otorhinolaryngologic diseases during lactation-which medications are compatible with breastfeeding?].

作者信息

Paulus Wolfgang E, Schwamborn Carolin, Friebe-Hoffmann Ulrike

机构信息

Klinik für Frauenheilkunde und Geburtshilfe, Universitätsklinikum Ulm, Ulm, Deutschland.

Beratungsstelle für Reproduktionstoxikologie, Universitätsfrauenklinik Ulm, Prittwitzstr. 43, 89075, Ulm, Deutschland.

出版信息

HNO. 2025 Sep;73(9):661-672. doi: 10.1007/s00106-025-01648-7. Epub 2025 Aug 4.

DOI:10.1007/s00106-025-01648-7
PMID:40759734
Abstract

Breastmilk is well established as the best source of nutrition for infants. Any interruption to breastfeeding comes with risks such as mastitis, decreased breastmilk supply, infant bottle refusal, and infant allergic reaction if formula is used. The majority of common medications used in general otolaryngology are safe for breastfeeding patients. Insufficient knowledge can lead to clinicians and patients alike being concerned about continued breastfeeding, resulting in interruption or cessation of breastfeeding. On the other hand, much-needed treatment is often withheld for fear of putting the infant at risk from contaminated breastmilk, which can disrupt the mother's wellbeing and, in turn, disturb a successful breastfeeding relationship. The aim of the present work is to present a structured "guideline for practice" pertaining to medication that can be used during lactation for treating medical conditions of the ear, nose, and throat.

摘要

母乳作为婴儿最佳的营养来源已得到充分认可。母乳喂养的任何中断都伴随着风险,如乳腺炎、母乳供应减少、婴儿拒奶瓶以及如果使用配方奶则会出现婴儿过敏反应。普通耳鼻喉科使用的大多数常用药物对哺乳期患者是安全的。知识不足可能导致临床医生和患者都担心继续母乳喂养,从而导致母乳喂养中断或停止。另一方面,由于担心婴儿因受污染的母乳而面临风险,急需的治疗往往被推迟,这可能会扰乱母亲的健康,进而破坏成功的母乳喂养关系。本研究的目的是提出一份结构化的“实践指南”,涉及哺乳期可用于治疗耳、鼻、喉疾病的药物。

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本文引用的文献

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BMC Pregnancy Childbirth. 2024 Dec 18;24(1):819. doi: 10.1186/s12884-024-07027-4.
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Topical and oral steroids for otitis media with effusion (OME) in children.局部和口服类固醇治疗儿童分泌性中耳炎(OME)。
Cochrane Database Syst Rev. 2023 Dec 13;12(12):CD015255. doi: 10.1002/14651858.CD015255.pub2.
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Medication Safety in Breastfeeding.
母乳喂养中的用药安全。
Am Fam Physician. 2022 Dec;106(6):638-644.
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Supporting Lactation in Otolaryngology Patients Through Medication Optimization, Radiology Considerations, and More: A Literature Review.通过优化药物治疗、放射学考虑等措施支持耳鼻喉科患者的母乳喂养:文献综述。
JAMA Otolaryngol Head Neck Surg. 2022 Oct 1;148(10):973-980. doi: 10.1001/jamaoto.2022.2286.
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Development of a Generic Physiologically-Based Pharmacokinetic Model for Lactation and Prediction of Maternal and Infant Exposure to Ondansetron via Breast Milk.建立通用的基于生理学的哺乳期药代动力学模型及通过母乳预测昂丹司琼在母亲和婴儿体内的暴露量。
Clin Pharmacol Ther. 2022 May;111(5):1111-1120. doi: 10.1002/cpt.2530. Epub 2022 Mar 5.
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Local Anesthesia and Breastfeeding.局部麻醉与母乳喂养
Breastfeed Med. 2021 Mar;16(3):173-174. doi: 10.1089/bfm.2020.0384. Epub 2020 Dec 28.
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Guideline on anaesthesia and sedation in breastfeeding women 2020: Guideline from the Association of Anaesthetists.2020 年母乳喂养妇女麻醉和镇静指南:麻醉师协会指南。
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Eur Respir J. 2020 Feb 6;55(2). doi: 10.1183/13993003.01208-2019. Print 2020 Feb.
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