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细胞中的空间驱动活性氧：对宇航员健康和食品安全的潜在威胁。

Space-driven ROS in cells: a hidden danger to astronaut health and food safety.

作者信息

Mokhtari Majid, Reinsch Sigrid S, Barcenilla Borja Barbero, Ziyaei Kobra, Barker Richard John

机构信息

Department of Bioinformatics, Kish International Campus, University of Tehran, Kish Island, Iran.

Space Biosciences Division, NASA Ames Research Center, Moffett Field, Santa Clara, CA, 94035, USA.

出版信息

NPJ Microgravity. 2025 Aug 4;11(1):52. doi: 10.1038/s41526-025-00492-x.

DOI:10.1038/s41526-025-00492-x
PMID:40759890
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12322194/
Abstract

Astronaut nutrition faces supply, logistics, and cost challenges, making space farming a solution. While plants adapt to space microgravity may trigger oxidative stress. Research shows space-grown plants achieve Earth-like growth, but ROS accumulation remains a concern. This study examines ROS buildup in cells and its risks for astronauts, emphasizing effects on homeostasis, disease pathways, gut microbiome, and nutrition. This research provides new insights into oxidative stress in space missions.

摘要

宇航员营养面临供应、物流和成本挑战，这使得太空种植成为一种解决方案。虽然植物适应太空微重力可能会引发氧化应激。研究表明，太空种植的植物能实现类似地球的生长，但活性氧的积累仍然是一个问题。本研究考察了细胞中活性氧的积累及其对宇航员的风险，重点强调了其对体内平衡、疾病途径、肠道微生物群和营养的影响。这项研究为太空任务中的氧化应激提供了新的见解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a30/12322194/05464fc33e34/41526_2025_492_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a30/12322194/2161b5bcc1d8/41526_2025_492_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a30/12322194/2694c28cbed4/41526_2025_492_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a30/12322194/628994715659/41526_2025_492_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a30/12322194/441b35067920/41526_2025_492_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a30/12322194/05464fc33e34/41526_2025_492_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a30/12322194/2161b5bcc1d8/41526_2025_492_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a30/12322194/2694c28cbed4/41526_2025_492_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a30/12322194/628994715659/41526_2025_492_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a30/12322194/441b35067920/41526_2025_492_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a30/12322194/05464fc33e34/41526_2025_492_Fig5_HTML.jpg

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本文引用的文献

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Hydroponics for plant cultivation in space - a white paper.水培在太空植物栽培中的应用——白皮书。
Life Sci Space Res (Amst). 2024 Nov;43:13-21. doi: 10.1016/j.lssr.2024.06.004. Epub 2024 Jun 26.
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The physiology of plants in the context of space exploration.太空探索背景下的植物生理学。
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New classifications for quantum bioinformatics: Q-bioinformatics, QCt-bioinformatics, QCg-bioinformatics, and QCr-bioinformatics.量子生物信息学的新分类：Q-生物信息学、QCt-生物信息学、QCg-生物信息学和 QCr-生物信息学。
Brief Bioinform. 2024 Jan 22;25(2). doi: 10.1093/bib/bbae074.
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Association between exposure to water sources contaminated with polycyclic aromatic hydrocarbons and cancer risk: A systematic review.多环芳烃污染水源暴露与癌症风险的关联：系统综述。
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Meta-analysis of the space flight and microgravity response of the Arabidopsis plant transcriptome.拟南芥植物转录组的太空飞行和微重力反应的荟萃分析。
NPJ Microgravity. 2023 Mar 20;9(1):21. doi: 10.1038/s41526-023-00247-6.
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The Key Roles of ROS and RNS as a Signaling Molecule in Plant-Microbe Interactions.活性氧和活性氮作为信号分子在植物-微生物相互作用中的关键作用
Antioxidants (Basel). 2023 Jan 25;12(2):268. doi: 10.3390/antiox12020268.
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Biomaterials. 2023 Apr;295:122053. doi: 10.1016/j.biomaterials.2023.122053. Epub 2023 Feb 17.
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Recent developments in space food for exploration missions: A review.探索任务中的太空食品最新进展：综述。
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