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Levels of chlorpromazine and its active metabolites in rat brain and the relationship to central monoamine metabolism and prolactin secretion.

作者信息

Alfredsson G, Wiesel F A, Skett P

出版信息

Psychopharmacology (Berl). 1977 Jun 6;53(1):13-8. doi: 10.1007/BF00426688.

DOI:10.1007/BF00426688
PMID:407609
Abstract
摘要

相似文献

1
Levels of chlorpromazine and its active metabolites in rat brain and the relationship to central monoamine metabolism and prolactin secretion.大鼠脑中氯丙嗪及其活性代谢物的水平以及与中枢单胺代谢和催乳素分泌的关系。
Psychopharmacology (Berl). 1977 Jun 6;53(1):13-8. doi: 10.1007/BF00426688.
2
The distribution and metabolism of chlorpromazine in rats and the relationship to effects on cerebral monoamine metabolism.氯丙嗪在大鼠体内的分布与代谢及其与对脑单胺代谢影响的关系。
Eur J Pharmacol. 1976 Dec;40(2):263-72. doi: 10.1016/0014-2999(76)90061-3.
3
Prostaglandin synthesis inhibition and monoamine metabolites in the rat brain.大鼠脑中前列腺素合成抑制与单胺代谢产物
Prostaglandins. 1979 Dec;18(6):837-45. doi: 10.1016/0090-6980(79)90121-7.
4
LSD: effect on monoamine metabolites in rat prefrontal cortex.麦角酸二乙酰胺（LSD）：对大鼠前额叶皮质中单胺代谢物的影响
Biochem Pharmacol. 1982 Dec 15;31(24):4093-6. doi: 10.1016/0006-2952(82)90665-7.
5
Role of biogenic amines in certain pathological conditions.生物胺在某些病理状况中的作用。
Brain Res. 1975 Apr 11;87(2-3):355-62. doi: 10.1016/0006-8993(75)90433-3.
6
Changes in rat brain monoamine turnover following chronic antidepressant administration.长期给予抗抑郁药后大鼠脑单胺代谢的变化。
Life Sci. 1980 Feb 11;26(6):423-9. doi: 10.1016/0024-3205(80)90160-5.
7
Correlation between 3H-haloperidol binding in the striatum and brain amine metabolism in the rat after treatment with neuroleptics.用抗精神病药物治疗后大鼠纹状体中3H-氟哌啶醇结合与脑胺代谢之间的相关性。
Life Sci. 1978 Aug 7;23(5):437-41. doi: 10.1016/0024-3205(78)90149-2.
8
Lisuride- and D-LSD-induced changes of monoamine turnover in the rat brain.利舒脲和D-麦角酸二乙酰胺引起的大鼠脑内单胺周转率变化。
Adv Biochem Psychopharmacol. 1978;19:393-6.
9
Binding of psychoactive drugs to rat brain amine receptors, measured ex vivo, and their effects on the metabolism of biogenic amines.精神活性药物与大鼠脑胺受体的结合（离体测定）及其对生物胺代谢的影响。
Naunyn Schmiedebergs Arch Pharmacol. 1986 Mar;332(3):258-66. doi: 10.1007/BF00504864.
10
Effect of melperone, two of its metabolites and thiothixene on central monoamine metabolism and prolactin levels in rodents.美哌隆及其两种代谢产物与硫利达嗪对啮齿动物中枢单胺代谢及催乳素水平的影响。
Acta Pharmacol Toxicol (Copenh). 1978 Aug;43(2):129-36. doi: 10.1111/j.1600-0773.1978.tb02246.x.

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Antihistamines, phenothiazine-based antipsychotics, and tricyclic antidepressants potently activate pharmacologically relevant human carbonic anhydrase isoforms II and VII.抗组胺药、吩噻嗪类抗精神病药和三环类抗抑郁药能强烈激活具有药理相关性的人碳酸酐酶同工酶 II 和 VII。
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2
Chlorpromazine, an Inverse Agonist of D1R-Like, Differentially Targets Voltage-Gated Calcium Channel (Ca) Subtypes in mPFC Neurons.氯丙嗪，一种类D1R反向激动剂，对内侧前额叶皮质（mPFC）神经元中的电压门控钙通道（Ca）亚型具有不同的靶向作用。
Mol Neurobiol. 2023 May;60(5):2644-2660. doi: 10.1007/s12035-023-03221-1. Epub 2023 Jan 25.
3

本文引用的文献

1
A COMPARATIVE STUDY OF CHLORPROMAZINE AND ITS DEMETHYLATED DERIVATIVES: POTENCY AND TISSUE DISTRIBUTION.氯丙嗪及其去甲基衍生物的比较研究：效能与组织分布
Biochem Pharmacol. 1964 Mar;13:539-41. doi: 10.1016/0006-2952(64)90178-9.
2
EFFECT OF CHLORPROMAZINE OR HALOPERIDOL ON FORMATION OF 3METHOXYTYRAMINE AND NORMETANEPHRINE IN MOUSE BRAIN.氯丙嗪或氟哌啶醇对小鼠脑内3-甲氧基酪胺和去甲变肾上腺素形成的影响。
Acta Pharmacol Toxicol (Copenh). 1963;20:140-4. doi: 10.1111/j.1600-0773.1963.tb01730.x.
3
Relevance of the N,N-dimethyl configuration to the pharmacological action of chlorpromazine.
Biotransformation of chlorpromazine and methdilazine by Cunninghamella elegans.
雅致小克银汉霉对氯丙嗪和甲哌氯丙嗪的生物转化
Appl Environ Microbiol. 1996 Mar;62(3):798-803. doi: 10.1128/aem.62.3.798-803.1996.
4
Alteration in the tranquilizing potency of chlorpromazine in rats exposed chronically to the insecticide, endosulfan.长期接触杀虫剂硫丹的大鼠中氯丙嗪镇静效力的改变。
Bull Environ Contam Toxicol. 1994 Nov;53(5):655-62. doi: 10.1007/BF00196936.
5
The presence of 7-hydroxychlorpromazine in CSF of chloropromazine-treated patients.
Psychopharmacology (Berl). 1982;77(4):376-8. doi: 10.1007/BF00432774.
6
The in vivo distribution of an antidepressant drug (DMI) in male and female rats.一种抗抑郁药物（地昔帕明）在雄性和雌性大鼠体内的分布。
Psychopharmacology (Berl). 1979 Nov;65(3):259-63. doi: 10.1007/BF00492213.
7
The effect of propranolol treatment in shizophrenia on CSF amine metabolites and prolactin.普萘洛尔治疗精神分裂症对脑脊液胺类代谢产物及催乳素的影响。
Psychopharmacology (Berl). 1979 Jun 21;63(3):293-6. doi: 10.1007/BF00433565.
8
Monoamine metabolite levels in cerebrospinal fluid of psychotic women treated with melperone or thiothixene.接受美哌隆或替沃噻吨治疗的精神病女性脑脊液中单胺代谢物水平。
Arch Psychiatr Nervenkr (1970). 1977 Oct 11;224(2):107-18. doi: 10.1007/BF00346479.
N，N - 二甲基构型与氯丙嗪药理作用的相关性。
Biochem Pharmacol. 1963 Jul;12:679-85. doi: 10.1016/0006-2952(63)90043-1.
4
Action and metabolism of chlorpromazine sulfoxide in man.人體中氯丙嗪亞碸的作用及代謝
J Pharmacol Exp Ther. 1957 Sep;121(1):8-12.
5
The metabolism of chlorpromazine by liver microsomal enzyme systems.氯丙嗪在肝脏微粒体酶系统中的代谢。
J Pharmacol Exp Ther. 1967 Aug;157(2):446-58.
6
Physiologic and clinical effects of chlorpromazine and their relationship to plasma level.氯丙嗪的生理和临床效应及其与血浆水平的关系。
Clin Pharmacol Ther. 1972 Nov-Dec;13(6):931-46. doi: 10.1002/cpt1972136931.
7
Effect of chlorpromazine and some of its metabolites on synthesis and turnover of catecholamines formed from 14 C-tyrosine in mouse brain.氯丙嗪及其某些代谢产物对小鼠脑内由¹⁴C-酪氨酸形成的儿茶酚胺合成及更新的影响。
Psychopharmacologia. 1972;26(2):155-60. doi: 10.1007/BF00422102.
8
Tissue localization of 7- and 8-hydroxychlorpromazines.
Toxicol Appl Pharmacol. 1974 Apr;28(1):8-17. doi: 10.1016/0041-008x(74)90125-2.
9
Increase of 3-methoxy-4-hydroxyphenylethylene glycol in rat brain by neuroleptic drugs.抗精神病药物使大鼠脑内3-甲氧基-4-羟基苯乙二醇增加。
Eur J Pharmacol. 1973 Aug;23(2):183-6. doi: 10.1016/0014-2999(73)90054-x.
10
The labelling of proteins to high specific radioactivities by conjugation to a 125I-containing acylating agent.通过与含¹²⁵I的酰化剂结合将蛋白质标记至高比放射性。
Biochem J. 1973 Jul;133(3):529-39. doi: 10.1042/bj1330529.