Otto D, Robinson G, Baumann S, Schroeder S, Mushak P, Kleinbaum D, Boone L
Environ Res. 1985 Oct;38(1):168-86. doi: 10.1016/0013-9351(85)90082-9.
Forty-nine children aged 6 to 12 years were evaluated for residual effects of lead exposure using psychometric, electrophysiological, and medical tests 5 years after initial assessment. The original range of blood lead (PbB) levels was 6-59 (mean = 28) micrograms/dl; the current range was 6-30 (mean = 14) micrograms/dl. A linear relationship between PbB and slow brain wave voltage during sensory conditioning was observed at initial evaluation and at 2-year follow-up. No significant relationship between PbB and slow wave voltage during passive conditioning was found at the 5-year follow-up, although a linear increase in slow wave negativity relative to the current PbB level during active conditioning was suggested by exploratory analyses. Another exploratory analysis revealed a significant linear relationship between the original PbB levels and the latency of waves III and V of the brainstem auditory evoked potential. The latency of both waves increased as a function of original PbB. Increased latency of these waves is suggestive of subclinical pathology of the auditory pathway rostral to the cochlear nucleus, although end-organ impairment cannot be ruled out. No threshold for the effect of Pb on auditory function was apparent.
对49名6至12岁儿童在初次评估5年后，使用心理测量、电生理和医学测试评估铅暴露的残留影响。最初血铅（PbB）水平范围为6 - 59（平均 = 28）微克/分升；当前范围为6 - 30（平均 = 14）微克/分升。在初次评估和2年随访时观察到PbB与感觉条件反射期间慢脑波电压之间存在线性关系。在5年随访时，未发现PbB与被动条件反射期间慢波电压之间存在显著关系，尽管探索性分析表明在主动条件反射期间慢波负向性相对于当前PbB水平呈线性增加。另一项探索性分析显示，最初的PbB水平与脑干听觉诱发电位的波III和波V潜伏期之间存在显著线性关系。这两个波的潜伏期均随最初的PbB水平而增加。这些波潜伏期的增加提示耳蜗核上方听觉通路的亚临床病理改变，尽管不能排除终末器官损伤。未发现铅对听觉功能影响的阈值。
