Zhang Xueyao, Chen Yanli, Hu Wenyu, Lu Saien, Yu Haijie, Sun Yingxian
Department of Cardiology, First Hospital of China Medical University, Shenyang, China.
Ann Med. 2025 Dec;57(1):2543524. doi: 10.1080/07853890.2025.2543524. Epub 2025 Aug 5.
The aim of this study is to evaluate the global burden trends of atrial fibrillation/flutter with attributable risk factors among adolescents and young adults from 1990 to 2021, particularly in the context of the increasing prevalence of cardiovascular diseases in younger populations.
Disease burden data for atrial fibrillation/atrial flutter were sourced from the 2021 Global Burden of Disease Study. The primary metrics were incidence, disability-adjusted life years, and mortality. Population attributable fractions were used to calculate the percentage contribution of the major underlying risk factors to the disease burden.
From 1990 to 2021, the global burden of atrial fibrillation/atrial flutter among the studied population increased by 57.26% in incidence, 71.32% in mortality, and 62.34% in disability-adjusted life years. The rate increases were 15.87%, 26.22%, and 19.61%, respectively. The burden of atrial fibrillation/atrial flutter in 2021 and its temporal trends varied significantly according to sex, sociodemographic index quintiles, and geographic location. In 2021, the burden was the highest in the middle-sociodemographic-index regions. Sex differences were found in all potential risk factors of atrial fibrillation/atrial flutter-related mortality and disability-adjusted life year rates. The top three potential risk factors in men were high systolic blood pressure, tobacco exposure, and high alcohol use, and in women, high systolic blood pressure, high body mass index, and tobacco exposure.
An imbalance in disease burden across different regions exists. The rapidly increasing disease burden warrants attention, and prevention and treatment strategies should be adjusted to prevent further increase.
本研究旨在评估1990年至2021年青少年和青年人心房颤动/扑动及其归因风险因素的全球负担趋势，特别是在年轻人群中心血管疾病患病率不断上升的背景下。
心房颤动/心房扑动的疾病负担数据来自2021年全球疾病负担研究。主要指标为发病率、伤残调整生命年和死亡率。人群归因分数用于计算主要潜在风险因素对疾病负担的贡献百分比。
1990年至2021年，研究人群中心房颤动/心房扑动的全球负担在发病率方面增加了57.26%，在死亡率方面增加了71.32%，在伤残调整生命年方面增加了62.34%。增长率分别为15.87%、26.22%和19.61%。2021年心房颤动/心房扑动的负担及其时间趋势因性别、社会人口学指数五分位数和地理位置而异。2021年，中等社会人口学指数地区的负担最高。在心房颤动/心房扑动相关死亡率和伤残调整生命年率的所有潜在风险因素中均发现了性别差异。男性的前三大潜在风险因素是收缩压高、烟草暴露和大量饮酒，女性的前三大潜在风险因素是收缩压高、体重指数高和烟草暴露。
不同地区存在疾病负担不平衡。疾病负担的快速增加值得关注，应调整预防和治疗策略以防止进一步增加。
