Shademan Behrouz, Karamad Vahidreza, Nourazarian Alireza, Biray Avci Cigir
Medical Journalism, School of Paramedical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.
Department of Medical Biology, Ege University Medical School, Izmir, Türkiye.
Front Oncol. 2025 Jul 21;15:1570093. doi: 10.3389/fonc.2025.1570093. eCollection 2025.
The discovery of microRNAs (miRNAs) and their pivotal role in gene regulation has opened up new avenues for innovative cancer treatments. Recent years have witnessed extensive research into the intricate mechanisms of miRNAs and their impact on solid tumors. These small non-coding RNA molecules are central to gene regulation and are frequently dysregulated in various cancers, particularly solid tumors. Dysregulation of specific miRNAs can initiate, progress, and metastasize tumors, making them appealing targets in cancer therapy. This article explores recent studies on identifying specific miRNAs associated with solid tumors and their influence on crucial signaling pathways. These findings enable precise targeting of cancer cells, reducing damage to healthy tissues and minimizing side effects commonly associated with conventional cancer treatments. Understanding the complex regulatory networks governed by miRNAs allows researchers and clinicians to develop highly effective, personalized treatment strategies, heralding a new era of tailored cancer medicine. Ongoing research in this field holds immense promise for pioneering targeted therapies that can significantly improve outcomes and the quality of life for individuals battling solid tumors.
微小RNA（miRNA）的发现及其在基因调控中的关键作用为创新的癌症治疗开辟了新途径。近年来，人们对miRNA的复杂机制及其对实体瘤的影响进行了广泛研究。这些小的非编码RNA分子是基因调控的核心，在各种癌症，尤其是实体瘤中经常失调。特定miRNA的失调可引发、促进肿瘤进展并使其转移，使其成为癌症治疗中具有吸引力的靶点。本文探讨了近期关于识别与实体瘤相关的特定miRNA及其对关键信号通路影响的研究。这些发现能够精确靶向癌细胞，减少对健康组织的损害，并将传统癌症治疗常见的副作用降至最低。了解由miRNA控制的复杂调控网络使研究人员和临床医生能够制定高效、个性化的治疗策略，开创了量身定制癌症医学的新时代。该领域正在进行的研究对于开拓靶向治疗具有巨大潜力，有望显著改善实体瘤患者的治疗效果和生活质量。
