Guo Pu, Mei Jing
Graduate School of Xinjiang Medical University, Urumqi, Xinjiang, China.
Department of Anesthesiology, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang, China.
Front Neurosci. 2025 Jul 21;19:1614362. doi: 10.3389/fnins.2025.1614362. eCollection 2025.
Neurotoxicity is a common toxic reaction associated with the use of the anesthetic drug propofol. With the widespread use of propofol, the issue of neurotoxicity has garnered significant attention. Mitochondria are the energy metabolism centers of cells and play a crucial role in biological processes such as cell growth and development, invasion and metastasis, division and differentiation, and apoptosis. Dynamin-related protein 1 (Drp1) is a key regulator of mitochondrial fission that can modulate the dynamic balance of mitochondria and plays an important role in maintaining mitochondrial morphology and function. The abnormal expression of Drp1 is closely related to the occurrence and development of various pathological conditions. Through a systematic review of multi-species animal and cellular studies, we elucidated the correlation between Drp1 and propofol-induced neurotoxicity. By analyzing Drp1-mediated mitochondrial fragmentation across different organ systems, this work provides crucial theoretical foundations for developing Drp1-targeted strategies in propofol neurotoxicity detection, prevention, and pharmacological intervention.
神经毒性是与麻醉药物丙泊酚使用相关的常见毒性反应。随着丙泊酚的广泛应用，神经毒性问题已引起广泛关注。线粒体是细胞的能量代谢中心，在细胞生长发育、侵袭转移、分裂分化及凋亡等生物学过程中发挥关键作用。动力相关蛋白1（Drp1）是线粒体分裂的关键调节因子，可调节线粒体的动态平衡，对维持线粒体形态和功能起重要作用。Drp1的异常表达与多种病理状况的发生发展密切相关。通过对多物种动物和细胞研究的系统综述，我们阐明了Drp1与丙泊酚诱导的神经毒性之间的相关性。通过分析Drp1介导的不同器官系统中的线粒体碎片化，这项工作为开发针对Drp1的策略用于丙泊酚神经毒性检测、预防及药理干预提供了关键的理论基础。
