Farahani Hadiseh, Ganji Ali, Mosayebi Ghasem, Monfared Mohsen Ebrahimi, Ghazavi Ali
Department of Immunology, School of Medicine, Arak University of Medical Sciences, Arak, Iran.
Molecular and Medicine Research Center, Arak University of Medical Sciences, Arak, Iran.
Int J Inflam. 2025 Jul 28;2025:8670048. doi: 10.1155/ijin/8670048. eCollection 2025.
Netrin-1, a central axonal guidance molecule discovered for its role in neuronal development, is also essential in neurodegenerative diseases. Netrin-1 inhibits leukocyte migration and inflammation-related tissue damage outside the central nervous system. Therefore, it can be viewed as a potential biomarker for inflammatory activity in neurodegenerative diseases. Recent studies highlight the dual roles of Netrin-1 in neuroinflammation and neurodegenerative diseases. In the context of neurodegeneration, Netrin-1 demonstrates both protective and harmful effects. This review highlights recent advancements in research regarding the dual roles of Netrin-1 in neuroinflammation and neurodegeneration. We discuss its involvement in protecting the blood-brain barrier (BBB) and regulating immune cell migration and its effects on various neurodegenerative diseases. A greater understanding of the multifunctionality of Netrin-1 could potentially be employed in developing new treatment modalities.
Netrin-1是一种因其在神经元发育中的作用而被发现的中枢轴突导向分子，在神经退行性疾病中也至关重要。Netrin-1抑制中枢神经系统外白细胞迁移和炎症相关的组织损伤。因此，它可被视为神经退行性疾病中炎症活动的潜在生物标志物。最近的研究突出了Netrin-1在神经炎症和神经退行性疾病中的双重作用。在神经退行性变的背景下，Netrin-1表现出保护和有害两种作用。本综述重点介绍了Netrin-1在神经炎症和神经退行性变中的双重作用的最新研究进展。我们讨论了它在保护血脑屏障（BBB）、调节免疫细胞迁移方面的作用及其对各种神经退行性疾病的影响。对Netrin-1多功能性的更深入理解可能会被用于开发新的治疗方法。
