Chai Chaoxin, Cui Yuqi, Li Meng, Xia Jianing, Wang Yiming, Ren Fuyun, Chen Liping
Department of Neurology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
Key Laboratory of Clinical Neurology (Hebei Medical University), Ministry of Education, Shijiazhuang, Hebei, China.
Front Neurol. 2025 Jul 21;16:1590408. doi: 10.3389/fneur.2025.1590408. eCollection 2025.
This study aims to investigate the association between uric acid (SUA) level and white matter hyperintensities (WMH) in patients with mild ischemic stroke.
This study retrospectively analyzed 290 patients with mild ischemic Stroke who were hospitalized at the Second Hospital of Hebei Medical University from March 2021 to January 2022. General clinical information and laboratory test results were collected. WMH was interpreted on MRI, and periventricular hyperintensity (PVH) and deep white matter hyperintensities (DWMH) were scored, respectively. According to the score of Fazekas, WMH was divided into two groups. Factors influencing WMH severity were analyzed, and the relationship between SUA and WMH was further explored. The results showed that the SUA of patients with moderate to severe DWMH was higher than that of patients with no or mild DWMH (345.10 ± 97.52 μmol/L vs. 317.99 ± 91.21 μmol/L, = 0.028). There was no significant difference in SUA between the moderate to severe PVH group and the no or mild PVH group (336.49 ± 99.29 μmol/L vs. 319.16 ± 89.92 μmol/L, = 0.131). Spearman correlation analysis showed that SUA was positively correlated with the severity of DWMH ( = 0.123, = 0.037), while SUA was not significantly correlated with PVH severity ( = 0.070, = 0.234). After adjusting for confounders by multifactor logistic regression, SUA was independently correlated with DWMH severity (OR: 1.005, 95% CI: 1.002-1.009, = 0.004). There was no significant correlation between SUA and PVH (OR: 1.003, 95% CI: 1.000-1.006 = 0.051).
SUA is an independent risk factor for DWMH in patients, and there is no significant correlation between SUA level and PVH.
本研究旨在探讨轻度缺血性脑卒中患者尿酸（SUA）水平与脑白质高信号（WMH）之间的关联。
本研究回顾性分析了2021年3月至2022年1月在河北医科大学第二医院住院的290例轻度缺血性脑卒中患者。收集了一般临床信息和实验室检查结果。通过磁共振成像（MRI）解读WMH，并分别对脑室周围高信号（PVH）和深部脑白质高信号（DWMH）进行评分。根据 Fazekas 评分，将WMH分为两组。分析影响WMH严重程度的因素，并进一步探讨SUA与WMH之间的关系。结果显示，中度至重度DWMH患者的SUA高于无或轻度DWMH患者（345.10 ± 97.52 μmol/L vs. 317.99 ± 91.21 μmol/L，P = 0.028）。中度至重度PVH组与无或轻度PVH组的SUA无显著差异（336.49 ± 99.29 μmol/L vs. 319.16 ± 89.92 μmol/L，P = 0.131）。Spearman相关性分析显示，SUA与DWMH严重程度呈正相关（r = 0.123，P = 0.037），而SUA与PVH严重程度无显著相关性（r = 0.070，P = 0.234）。通过多因素逻辑回归调整混杂因素后，SUA与DWMH严重程度独立相关（OR：1.005，95%CI：1.002 - 1.009，P = 0.004）。SUA与PVH之间无显著相关性（OR：1.003，95%CI：1.000 - 1.006，P = 0.051）。
SUA是患者DWMH的独立危险因素，SUA水平与PVH之间无显著相关性。
