Czyz Sonia, Yang Kerry, Jafarian Fatemeh
Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Division of Dermatology, Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Front Pediatr. 2025 Jul 21;13:1599491. doi: 10.3389/fped.2025.1599491. eCollection 2025.
Benzoyl peroxide is a widely used and effective topical treatment for acne vulgaris, particularly in pediatric and adolescent populations. Despite its established safety profile, recent concerns emerged regarding its potential to decompose into benzene, a known carcinogen, under specific environmental conditions, like elevated temperatures and exposure to ultraviolet radiation. In this paper we review the management of acne vulgaris in pediatric patients, examine the evidence supporting benzoyl peroxide use and explore the recent studies evaluating the association between benzoyl peroxide use and malignancy risk. While initial reports raised alarm over benzene formation, subsequent investigations have not demonstrated an increased risk of hematologic malignancies. Here, we assess the strengths and limitations of existing evidence and identify future research priorities. Additionally, we provide recommendations for the safe and evidence-based use of benzoyl peroxide in pediatric acne treatment.
过氧化苯甲酰是一种广泛使用且有效的寻常痤疮局部治疗药物，尤其适用于儿童和青少年人群。尽管其安全性已得到确立，但近期出现了一些担忧，即它在特定环境条件下（如高温和紫外线照射）可能分解为已知致癌物苯。在本文中，我们回顾了儿科患者寻常痤疮的管理，审视了支持使用过氧化苯甲酰的证据，并探讨了近期评估过氧化苯甲酰使用与恶性肿瘤风险之间关联的研究。虽然最初的报告对苯的形成发出了警报，但后续调查并未表明血液系统恶性肿瘤的风险增加。在此，我们评估现有证据的优势和局限性，并确定未来的研究重点。此外，我们还为在儿科痤疮治疗中安全且基于证据地使用过氧化苯甲酰提供建议。
