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1-苯并[][1,3]恶嗪-2,4-二酮简便高效合成方法的研究。

Investigation for the easy and efficient synthesis of 1-benzo[][1,3]oxazine-2,4-diones.

作者信息

Mitsostergios Nikolaos, Athanasopoulos Vasileios, Mourtas Spyridon

机构信息

Department of Chemistry, University of Patras 26510 Rio Patras Greece

出版信息

RSC Adv. 2025 Aug 4;15(34):27644-27651. doi: 10.1039/d5ra04014k. eCollection 2025 Aug 1.

DOI:10.1039/d5ra04014k
PMID:40761901
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12320480/
Abstract

We investigated a two-step approach for the easy and efficient synthesis of 1-benzo[][1,3]oxazine-2,4-diones starting from 2-aminobenzoic acids, using the urethane type fluorenylmethyloxycarbonyl (Fmoc), benzyloxycarbonyl (Cbz) and ethyloxycarbonyl (EtOCO) groups as the source of carbonyloxy group, and thionyl chloride to promote activation, cyclization and 1-benzo[][1,3]oxazine-2,4-diones formation.

摘要

我们研究了一种两步法，以2-氨基苯甲酸为起始原料，使用氨基甲酸酯型芴甲氧羰基（Fmoc）、苄氧羰基（Cbz）和乙氧羰基（EtOCO）基团作为羰氧基的来源，并利用亚硫酰氯促进活化、环化以及1-苯并[][1,3]恶嗪-2,4-二酮的形成，从而简便高效地合成1-苯并[][1,3]恶嗪-2,4-二酮。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9f2/12320480/77cdf42b00a5/d5ra04014k-s6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9f2/12320480/a5bd6677256a/d5ra04014k-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9f2/12320480/034a05134dac/d5ra04014k-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9f2/12320480/10ee294134f2/d5ra04014k-s2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9f2/12320480/4711cfbc78fb/d5ra04014k-s3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9f2/12320480/a664b3f2ee81/d5ra04014k-s4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9f2/12320480/39730dbdfe7c/d5ra04014k-s5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9f2/12320480/9f6a32edbbb4/d5ra04014k-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9f2/12320480/77cdf42b00a5/d5ra04014k-s6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9f2/12320480/a5bd6677256a/d5ra04014k-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9f2/12320480/034a05134dac/d5ra04014k-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9f2/12320480/10ee294134f2/d5ra04014k-s2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9f2/12320480/4711cfbc78fb/d5ra04014k-s3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9f2/12320480/a664b3f2ee81/d5ra04014k-s4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9f2/12320480/39730dbdfe7c/d5ra04014k-s5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9f2/12320480/9f6a32edbbb4/d5ra04014k-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9f2/12320480/77cdf42b00a5/d5ra04014k-s6.jpg

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