1-苯并[][1,3]恶嗪-2,4-二酮简便高效合成方法的研究。
Investigation for the easy and efficient synthesis of 1-benzo[][1,3]oxazine-2,4-diones.
作者信息
Mitsostergios Nikolaos, Athanasopoulos Vasileios, Mourtas Spyridon
机构信息
Department of Chemistry, University of Patras 26510 Rio Patras Greece
出版信息
RSC Adv. 2025 Aug 4;15(34):27644-27651. doi: 10.1039/d5ra04014k. eCollection 2025 Aug 1.
We investigated a two-step approach for the easy and efficient synthesis of 1-benzo[][1,3]oxazine-2,4-diones starting from 2-aminobenzoic acids, using the urethane type fluorenylmethyloxycarbonyl (Fmoc), benzyloxycarbonyl (Cbz) and ethyloxycarbonyl (EtOCO) groups as the source of carbonyloxy group, and thionyl chloride to promote activation, cyclization and 1-benzo[][1,3]oxazine-2,4-diones formation.
我们研究了一种两步法，以2-氨基苯甲酸为起始原料，使用氨基甲酸酯型芴甲氧羰基（Fmoc）、苄氧羰基（Cbz）和乙氧羰基（EtOCO）基团作为羰氧基的来源，并利用亚硫酰氯促进活化、环化以及1-苯并[][1,3]恶嗪-2,4-二酮的形成，从而简便高效地合成1-苯并[][1,3]恶嗪-2,4-二酮。
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