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[Rhino-sinusal mucormycosis in a solid organ transplant recipient].

作者信息

Moulan Lucie, Léonard Philippe, Hayette Marie-Pierre, Detrembleur Nancy, Bonvoisin Catherine, Weekers Laurent, Rogister Florence, Jouret François, Bouquegneau Antoine

机构信息

Service de Néphrologie, Dialyse et Transplantation, CHU Liège, Belgique.

Service des Maladies infectieuses, CHU Liège, Belgique.

出版信息

Rev Med Liege. 2025 Jul;80(7-8):517-521.

Abstract

We report on a 46-year-old female patient with a recent history of kidney transplantation who presented with acute sinusitis. Further investigation revealed rhino-sinusal mucormycosis. Surgical debridement and a five-month antifungal treatment along with the cessation of the immunosuppressive therapy were needed. This approach led to clinical improvement but unfortunately resulted in the loss of the allograft. More than two years after this infection, the clinical and endoscopic outcomes remain favourable. Mucormycosis is a rare opportunistic infection caused by fungi of the Mucorales order, characterized by angio-invasive properties that lead to thrombosis, necrosis and infarction of the affected tissues. Diagnosis primarily relies on imaging, microbiological studies and histopathological examination. Early detection and prompt management are crucial given the poor prognosis of mucormycosis. Treatment involves a combination of surgical debridement, antifungal therapy and management of risk factors such as immunosuppression. Despite an appropriate treatment, mucormycosis remains a serious and potentially life-threatening condition.

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