Davis S L, Anfinson M S, Klindt J, Ohlson D L
Prostaglandins. 1977 Jun;13(6):1209-20. doi: 10.1016/0090-6980(77)90146-0.
A series of experiments were conducted in ewes and whether (castrate male) lambs to evaluate the influence of prostaglandins on secretion of anabolic hormones and to determine if repeated injections of prostaglandin (PG) F2alpha would chronically influence the secretion of these hormones and perhaps growth rate as well. A single intravenous injection of PGA1 and PGB1 (100 microgram/kg) exerted no significant (P greater than .10) influence on plasma concentrations of prolactin (PRL), growth hormone (GH) or thyrotropin (TSH) in ewes. PGA1, but not PGB1, stimulated an increase in the plasma concentration of insulin. Infusion of PGF2alpha for 5.5 hr into ewes resulted in increased (P less than .05) plasma concentrations of both GH and ARL while TSH and insulin were not significantly influenced. Prostaglandin F2alpha, when injected subcutaneously into wether lambs (10 mg twice weekly) stimulated (P less than .05) plasma GH concentrations after the first injection, but not after 3 weeks of treatment. Changes in plasma PRL or TSH were not observed consistently in the lambs treated chronically with PGF2alpha or TRH. Prostaglandin F2alpha, in the present studies, and PGE1 in previously reported studies (1-3), has been demonstrated to be stimulatory to the secretion of PRL and GH. In contrast, PGA1 and PGB1, which lack an 11-hydroxyl group, failed to influence the secretion of either PRL or GH. It would, therefore, appear that the 11-hydroxyl group is a structural requirement for prostaglandins to influence the secretion of these two hormones in sheep. Treatment with thyrotropin releasing hormone (TRH), alone or in combination with PGF 2alpha, significantly (P less than .05) increased growth rate (average daily gains) while PGF2alpha did not, despite the fact that both compounds exerted similar effects on plasma GH.
在母羊和去势公羊羔身上进行了一系列实验，以评估前列腺素对合成代谢激素分泌的影响，并确定重复注射前列腺素（PG）F2α是否会长期影响这些激素的分泌，以及是否也会影响生长速度。单次静脉注射PGA1和PGB1（100微克/千克）对母羊血浆中催乳素（PRL）、生长激素（GH）或促甲状腺激素（TSH）的浓度没有显著（P大于0.10）影响。PGA1，但不是PGB1，刺激胰岛素血浆浓度升高。向母羊输注PGF2α 5.5小时导致GH和ARL的血浆浓度升高（P小于0.05），而TSH和胰岛素没有受到显著影响。将前列腺素F2α皮下注射到去势公羊羔体内（每周两次，每次10毫克），第一次注射后刺激（P小于0.05）血浆GH浓度升高，但治疗3周后没有。在用PGF2α或促甲状腺激素释放激素（TRH）长期治疗的羊羔中，血浆PRL或TSH的变化没有一致观察到。在本研究中的前列腺素F2α，以及先前报道的研究（1 - 3）中的PGE1，已被证明对PRL和GH的分泌有刺激作用。相比之下，缺乏11 - 羟基的PGA1和PGB1未能影响PRL或GH的分泌。因此，似乎11 - 羟基是前列腺素影响绵羊这两种激素分泌的结构要求。单独或与PGF 2α联合使用促甲状腺激素释放激素（TRH）治疗显著（P小于0.05）提高了生长速度（平均日增重），而PGF2α没有，尽管这两种化合物对血浆GH有相似的影响。
