Prince Priscilla, Naragon-Gainey Kristin, Becerra Rodrigo, Weinborn Michael, Pestell Carmela F
School of Psychological Science, The University of Western Australia, Perth, Australia.
Neuropsychol Rev. 2025 Aug 5. doi: 10.1007/s11065-025-09674-6.
This systematic review investigates the long-term trajectories of depressive symptoms in individuals with acquired brain injury (ABI) and identifies factors predicting group membership in these trajectories. The review follows the PRISMA guidelines and is registered on the International Platform of Registered Systematic Review and Meta-analysis Protocols (INPLASY-2023-11-0013). A comprehensive search of MEDLINE, PSYCINFO, EMBASE, CINHALPlus, ScienceDirect, Scopus, and Web of Science identified peer-reviewed studies published in English on adults aged 16 and above with an ABI diagnosis. Studies were included if they used a validated depression measure, had at least three assessment points, and applied group-based trajectory modelling. Exclusion criteria included studies focusing on neurodegenerative or neurodevelopmental disorders, or solely on treatments. The methodological quality was assessed using Joanna Briggs' critical appraisal tool. The review synthesised data from ten studies involving 13,205 participants (average age 51.38 years, 55.86% male). Four depressive symptom trajectory groups were identified with varying prevalence: stable low (68%), persistent high (13%), increasing (20%), and decreasing (11%). Several key predictors including sex, age, injury severity, and education emerged as significant predictors of group membership in the persistent high, increasing, and decreasing depressive groups. However, variability in study methodologies and sample compositions posed challenges to direct comparison. Nonetheless, the review underscores the importance of long-term monitoring and the development of tailored interventions, as depression can manifest or intensify years post-injury. Understanding depressive symptom trajectories could help create personalised interventions, improving quality of life for those with depression after ABI.
本系统评价调查了获得性脑损伤（ABI）患者抑郁症状的长期轨迹，并确定了预测这些轨迹中分组的因素。该评价遵循PRISMA指南，并已在国际注册系统评价和荟萃分析方案平台（INPLASY-2023-11-0013）上注册。通过对MEDLINE、PSYCINFO、EMBASE、CINHALPlus、ScienceDirect、Scopus和Web of Science进行全面检索，确定了以英文发表的关于16岁及以上ABI诊断成年人的同行评审研究。如果研究使用了经过验证的抑郁测量方法、至少有三个评估点并应用了基于组的轨迹模型，则纳入研究。排除标准包括专注于神经退行性或神经发育障碍或仅专注于治疗的研究。使用乔安娜·布里格斯的批判性评价工具评估方法学质量。该评价综合了来自10项研究的数据，涉及13205名参与者（平均年龄51.38岁，55.86%为男性）。确定了四个抑郁症状轨迹组，患病率各不相同：稳定低（68%）、持续高（13%）、上升（20%）和下降（11%）。几个关键预测因素，包括性别、年龄、损伤严重程度和教育程度，成为持续高、上升和下降抑郁组中分组的重要预测因素。然而，研究方法和样本构成的差异给直接比较带来了挑战。尽管如此，该评价强调了长期监测和制定量身定制干预措施的重要性，因为抑郁症可能在受伤数年之后出现或加重。了解抑郁症状轨迹有助于制定个性化干预措施，提高ABI后抑郁症患者的生活质量。
