Polho Gabriel Berlingieri, Shinkado Yumi Ricucci, Murazawa Leticia Kimie, Oliveira Vinicius Vitor, Pinheiro Victor Rocha, Pineda Labanda Diana Del Cisne, Barroso-Sousa Romualdo, Carvalho Barros Luciana Rodrigues, Testa Laura, Bonadio Renata Colombo
Instituto do Câncer do Estado de São Paulo, Brazil, Av. Dr. Arnaldo, 251 - Cerqueira Cesar, São Paulo, SP, Brazil.
Dasa Oncology, Brasilia Hospital, SHIS QI 15, Lago Sul, Brasília, Brazil.
Breast. 2025 Aug 4;83:104553. doi: 10.1016/j.breast.2025.104553.
Triple-negative breast cancer (TNBC) is associated with an increased risk of distant metastases. While pathological complete response (pCR) after neoadjuvant chemotherapy predicts favorable outcomes, data suggest it may not uniformly protect against central nervous system (CNS) relapse. This study analyzed 774 TNBC patients to assess recurrence patterns. While CNS recurrences were numerically lower in pCR patients (5.0 % vs 8.8 %, p = 0.11), they represented a significantly higher proportion of all relapses in this group (50.0 % vs 20.2 %, p = 0.003). These results suggest that while pCR reduces overall recurrence risk, there is a distinct pattern of CNS-predominant failure.
三阴性乳腺癌（TNBC）与远处转移风险增加相关。虽然新辅助化疗后的病理完全缓解（pCR）预示着良好的预后，但数据表明它可能无法一致地预防中枢神经系统（CNS）复发。本研究分析了774例TNBC患者以评估复发模式。虽然pCR患者的CNS复发在数量上较低（5.0%对8.8%，p = 0.11），但它们在该组所有复发中所占比例显著更高（50.0%对20.2%，p = 0.003）。这些结果表明，虽然pCR降低了总体复发风险，但存在以CNS为主的明显失败模式。
