Fusaric acid-induced elevation of homovanillic acid in the CSF as an index of brain noradrenaline synthesis.
作者信息
Elghozi J L, Laude D, Chaouloff F
出版信息
Eur J Pharmacol. 1985 Nov 19;117(3):363-7. doi: 10.1016/0014-2999(85)90010-x.
PMID:4076351
Abstract
The effect of the dopamine-beta-hydroxylase inhibitor, fusaric acid (FA), on cerebrospinal fluid (CSF) homovanillic acid (HVA) was studied in pentobarbitone-anesthetized rats. Idazoxan, a selective alpha 2-antagonist, accentuated the FA-induced HVA elevation in CSF while alpha-methyldopa pretreatment prevented this effect of FA on the HVA level in CSF. These results could indicate that the rate of dopamine synthesis in noradrenaline neurons could be the main determinant of the FA-induced HVA elevation.
摘要
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引用本文的文献
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Peripheral and central short-term effects of fusaric acid, a DBH inhibitor, on tryptophan and serotonin metabolism in the rat.DBH抑制剂富马酸对大鼠色氨酸和5-羟色胺代谢的外周和中枢短期影响。
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