Xing Shuyi, Liu Bingbing, He Luning, Feng Shuaipeng, Nan Kaisheng, Di Donghua, Gao Yikun, Wang Siling, Zhao Yunbo, Zhao Qinfu
Department of Microbial and Biochemical Pharmacy, School of Life Sciences and Biopharmaceuticals, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, Liaoning 110016, China.
Department of Biomedical Engineering, School of Medical Devices, Shenyang Pharmaceutical University, Shenyang 110016, China.
Acta Biomater. 2025 Aug 5. doi: 10.1016/j.actbio.2025.07.065.
Topics of wound healing have gained increasing attention, and wound healing is a complex dynamic process involving multiple stages and cytokines interactions. The causes of wound formation include physical injury, burns, frostbite resulting in ulcers or abscesses, and chronic diseases such as diabetes. All of these factors can lead to varying degrees of tissue damage. Infectious wound-related diseases are a major public safety concern, affecting the healthy lives of millions of people. Nanozymes, as a new artificial enzyme with the advantages of low cost and good stability, can effectively mimic natural enzyme activity and regulate the wound microenvironment to achieve the alleviation of oxidative stress, lowering of blood glucose, reconstruction of blood vessels, and promotion of infected wound healing. Therapies based on nanozymes and their related strategies have been extensively tapped in wound healing. This review explores the catalytic mechanism of nanozymes for wound treatment and their design directions, which provides readers with ideas for further research on the design of rational nanozymes. In addition, we have systematically explored their synergistic therapy. The clinical potentialities and future trials of nanozymes in boosting antimicrobial wound healing are accentuated in the final part. STATEMENT OF SIGNIFICANCE: Infected wound healing remains a significant challenge in the medical field. Traditional wound treatments are confronted with issues such as antibiotic resistance and limited effectiveness in promoting tissue repair. However, nanozymes, with their unique enzyme-like catalytic activities and nanomaterial properties, have emerged as a promising alternative. Nanozymes can effectively regulate the wound microenvironment to alleviate oxidative stress and inflammation, thereby promoting the healing of infected wounds. In this article, we comprehensively and systematically summarize the latest progress in nanozyme-based wound healing therapies, as well as the strategies for improving current nanozyme-based therapeutic approaches. Moreover, we elaborate on the role of nanozymes in the treatment of infected wounds from multiple perspectives, present examples of the combination of nanozymes with various other wound healing treatment methods, and summarize nanozyme-based delivery systems.
伤口愈合的话题日益受到关注，伤口愈合是一个复杂的动态过程，涉及多个阶段以及细胞因子的相互作用。伤口形成的原因包括物理损伤、烧伤、冻伤导致的溃疡或脓肿，以及糖尿病等慢性疾病。所有这些因素都会导致不同程度的组织损伤。与感染性伤口相关的疾病是一个重大的公共安全问题，影响着数百万人的健康生活。纳米酶作为一种新型人工酶，具有成本低、稳定性好等优点，能够有效模拟天然酶的活性，调节伤口微环境，从而实现减轻氧化应激、降低血糖、血管重建以及促进感染伤口愈合的目的。基于纳米酶及其相关策略的治疗方法在伤口愈合方面已得到广泛探索。本综述探讨了纳米酶用于伤口治疗的催化机制及其设计方向，为读者进一步开展合理的纳米酶设计研究提供思路。此外，我们还系统地探讨了它们的协同治疗作用。最后一部分着重阐述了纳米酶在促进抗菌伤口愈合方面的临床潜力和未来试验。意义声明：感染性伤口愈合仍是医学领域的一项重大挑战。传统的伤口治疗面临着抗生素耐药性以及促进组织修复效果有限等问题。然而，纳米酶凭借其独特的类酶催化活性和纳米材料特性，已成为一种有前途的替代方案。纳米酶能够有效调节伤口微环境，减轻氧化应激和炎症，从而促进感染伤口的愈合。在本文中，我们全面系统地总结了基于纳米酶的伤口愈合治疗的最新进展，以及改进当前基于纳米酶治疗方法的策略。此外，我们从多个角度阐述了纳米酶在感染伤口治疗中的作用，列举了纳米酶与其他各种伤口愈合治疗方法联合使用的实例，并总结了基于纳米酶的递送系统。
