Alghali S T, Hagan P, Robinson M
Exp Parasitol. 1985 Dec;60(3):364-70. doi: 10.1016/0014-4894(85)90043-8.
In mice concurrently infected with Hymenolepis citelli and Nematospiroides dubius, survival of the tapeworm was prolonged, and there was an impairment of the efferent arm of the response to the cestode. The immunological rejection of a six cysticercoid primary H. citelli infection was delayed by the N. dubius infection. The growth of the cestode was poorer in concurrently infected mice, and this effect was rapid, being evident within 4 days of the N. dubius infection. Maximum biomass in the controls was reached on Day 20, whereas in the concurrently infected mice it was reached on Day 25. The induction of acquired immunity to homologous H. citelli infection was suppressed, although the expression of a secondary response against homologous challenge was not abrogated in doubly infected mice. The results are discussed with reference to the immunodepressive effects the nematode is known to have on heterologous antigenic stimulation.
在同时感染微小膜壳绦虫和 dubius 旋毛虫的小鼠中，绦虫的存活期延长，并且对该绦虫反应的传出臂出现损伤。dubius 旋毛虫感染延迟了对六头微小膜壳绦虫原头蚴初次感染的免疫排斥。在同时感染的小鼠中，绦虫的生长较差，且这种影响迅速，在 dubius 旋毛虫感染后 4 天内就很明显。对照组在第 20 天达到最大生物量，而在同时感染的小鼠中则在第 25 天达到。对同源微小膜壳绦虫感染获得性免疫的诱导受到抑制，尽管在双重感染的小鼠中针对同源攻击的二次反应表达并未消除。参考已知该线虫对异源抗原刺激具有的免疫抑制作用对结果进行了讨论。
