Kotsias B A, Muchnik S
Experientia. 1985 Dec 15;41(12):1538-40. doi: 10.1007/BF01964795.
In the presence of verapamil (0.1 mM) rat soleus muscle fibers failed to generate action potentials with overshoots. In fibers with their Vm set to a local level of -90 mV, verapamil produces a gradual reduction in the amplitude of the repetitive action potentials; this effect is more pronounced at high rates of stimulation (100 Hz). Our results suggest a local anesthetic action of this drug that could contribute with its calcium channel blocking effect to the diminished mechanical tension observed in the presence of the drug.
在维拉帕米（0.1 mM）存在的情况下，大鼠比目鱼肌纤维无法产生具有超射的动作电位。在将其膜电位（Vm）设定为 -90 mV 局部水平的纤维中，维拉帕米会使重复性动作电位的幅度逐渐降低；这种效应在高刺激频率（100 Hz）时更为明显。我们的结果表明，这种药物具有局部麻醉作用，其钙通道阻断作用可能导致在该药物存在时观察到的机械张力降低。
