Levey Nadine, Bakhshaie Jafar, Vranceanu Ana-Maria, Greenberg Jonathan
Center for Health Outcomes and Interdisciplinary Research, MA General Hospital, Boston, Massachusetts, USA.
Harvard Medical School, Boston, Massachusetts, USA.
J Integr Complement Med. 2025 Aug 6. doi: 10.1177/27683605251363177.
We recently developed and established the feasibility of the first mind-body program aiming to prevent persistent concussion symptoms among young adults with anxiety - the Toolkit for Optimal Recovery after Concussion (TOR-C) and an active health education control (HE-C). Both interventions demonstrated preliminary improvements between baseline and post-intervention in outcomes including post-concussion symptoms, physical function, and anxiety. Here, we report on these outcomes 3 months post-intervention. Fifty young adults (ages 18-35) with a recent concussion (3-10 weeks) and anxiety (≥5 on GAD-7) were randomized to TOR-C ( = 25) or HE-C ( = 25). Participants completed measures of concussion symptoms (PCSS), anxiety (GAD-7), and physical function (WHODAS 2.0) at baseline (pre-randomization), post-intervention, and 3 months post-intervention. We used mixed-model ANOVA with a shared baseline to adjust for baseline differences and assessed within-group changes in these outcomes from baseline to 3 months. Preliminary improvements in concussion symptoms from baseline to 3 months post-intervention were statistically significant in both groups, but clinically meaningful (i.e., exceeding the Minimal Clinically Important Difference) only for TOR-C. Baseline versus 3-month follow-up improvements in physical function and anxiety were statistically significant and clinically meaningful for both groups. Findings provide preliminary evidence that TOR-C may help improve post-concussion recovery, and support a future fully-powered trial to establish the efficacy and sustained effects of TOR-C versus HE-C.
我们最近开发并确立了首个旨在预防焦虑症青年成年人持续性脑震荡症状的身心计划——脑震荡后最佳恢复工具包（TOR-C）以及积极健康教育对照组（HE-C）的可行性。两种干预措施在基线至干预后期间，在包括脑震荡后症状、身体功能和焦虑等结果方面均显示出初步改善。在此，我们报告干预后3个月的这些结果。五十名近期脑震荡（3 - 10周）且患有焦虑症（GAD-7评分≥5）的青年成年人（年龄18 - 35岁）被随机分为TOR-C组（n = 25）或HE-C组（n = 25）。参与者在基线（随机分组前）、干预后以及干预后3个月完成了脑震荡症状（PCSS）、焦虑（GAD-7）和身体功能（WHODAS 2.0）的测量。我们使用具有共享基线的混合模型方差分析来调整基线差异，并评估这些结果从基线到3个月的组内变化。从基线到干预后3个月，两组脑震荡症状的初步改善在统计学上均具有显著意义，但仅TOR-C组具有临床意义（即超过最小临床重要差异）。两组在身体功能和焦虑方面从基线到3个月随访的改善在统计学上具有显著意义且具有临床意义。研究结果提供了初步证据，表明TOR-C可能有助于改善脑震荡后的恢复，并支持未来进行一项全面的试验，以确定TOR-C与HE-C相比的疗效和持续效果。
