在检测伴有快速眼动睡眠行为障碍（RBD）的早期帕金森病黑质纹状体改变方面，γ-氨基丁酸（GABA）比铁和神经黑色素表现更优。
GABA outperforms iron and neuromelanin in detecting nigrostriatal alterations in early-stage Parkinson's disease with RBD.
作者信息
Zhang Youmin, Huang Pei, Liu Peng, Li Yan, Jin Zhijia, Yu Qiurong, Shi Xiaofeng, Liu Yu, Cheng Zenghui, Wu Peng, Weng Jinyuan, Liu Fangtao, Haacke Ewart Mark, Cui Ying, Chen Shengdi, He Naying, Yan Fuhua
机构信息
Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Faculty of Medical Imaging Technology, College of Health Science and Technology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
出版信息
NPJ Parkinsons Dis. 2025 Aug 5;11(1):229. doi: 10.1038/s41531-025-01096-8.
This study aimed to examine variations in iron deposition, neuromelanin (NM) content, gamma-aminobutyric acid (GABA) and glutamate-glutamine complex (Glx) levels within the nigrostriatal pathway in early-stage Parkinson's disease (PD) patients with and without Rapid Eye Movement Sleep Behavior Disorder (RBD). Twenty-two early-stage PD patients with RBD (PD-RBD), 33 without RBD (PD-nRBD), and 36 healthy controls (HC) were prospectively recruited and underwent 3 T MRI and H-MRS scans. GABA levels in the left basal ganglia were elevated in PD-nRBD versus HC (P = 0.014), whereas they were decreased in the PD-RBD relative to the PD-nRBD (P = 0.018). Iron deposition and NM content in the bilateral substantia nigra (SN) showed no differences between PD subgroups. Despite similar SN iron and NM content, the GABAergic system alteration provides novel insights into the pathophysiology of RBD in PD.
本研究旨在检测伴或不伴快速眼动睡眠行为障碍（RBD）的早期帕金森病（PD）患者黑质纹状体通路中铁沉积、神经黑素（NM）含量、γ-氨基丁酸（GABA）和谷氨酰胺-谷氨酸复合物（Glx）水平的变化。前瞻性招募了22例伴RBD的早期PD患者（PD-RBD）、33例不伴RBD的患者（PD-nRBD）和36例健康对照者（HC），并对其进行3T磁共振成像（MRI）和氢磁共振波谱（H-MRS）扫描。与HC相比，PD-nRBD患者左侧基底节的GABA水平升高（P = 0.014），而与PD-nRBD相比，PD-RBD患者的GABA水平降低（P = 0.018）。PD亚组之间双侧黑质（SN）的铁沉积和NM含量无差异。尽管SN中铁和NM含量相似，但GABA能系统的改变为PD中RBD的病理生理学提供了新的见解。
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