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前交叉韧带修复与重建:不同撕裂特征结局的荟萃分析

ACL repair vs. reconstruction: a meta-analysis of outcomes across different tear characteristics.

作者信息

Zheng Hongcheng, Zeng Yongtao, Daoerji Nacke, Wang Husen, Tang Bin, Shu Li

机构信息

The Sixth Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, 86830001, China.

出版信息

BMC Surg. 2025 Aug 5;25(1):339. doi: 10.1186/s12893-025-03101-6.

Abstract

BACKGROUND

Anterior cruciate ligament (ACL) reconstruction remains the gold standard but carries donor-site morbidity and prolonged recovery. Modern ACL repair techniques theoretically preserve native proprioception and enable faster rehabilitation. We hypothesized that modern ACL repair would demonstrate non-inferior clinical outcomes compared to reconstruction.This meta-analysis compares clinical outcomes of primary repair versus autograft reconstruction.

METHODS

We systematically searched PubMed, Cochrane Library, and Web of Science (2015–2025) for comparative studies (RCTs, cohorts, case-controls) reporting ≥ 2 key outcomes (failure rate, AP knee laxity, IKDC, Lysholm, or Tegner scores) with ≥ 1-year follow-up. Pooled ORs and WMDs with 95% CIs were calculated using RevMan 5.4. Subgroup analyses (injury-to-surgery time, injury location, study design, repair technique) and GRADE assessment were performed.

RESULTS

Fourteen studies (4 RCTs, 8 cohorts, 2 case-controls;  = 908 patients) were included (repair:  = 460; reconstruction:  = 448). Failure/Revision Rates: Repair demonstrated numerically higher failure rates (OR = 2.24, 95% CI 1.30–3.86,  = 0.004) and revision rates (OR = 2.01, 95% CI 1.21–3.33,  = 0.007) versus reconstruction.Hardware removal: increased hardware removal incidence was observed in repair groups (OR = 8.19, 95% CI 2.89–23.20,  < 0.001).AP knee laxity: reconstruction showed marginally lower AP knee laxity (WMD = 0.30, 95% CI 0.06–0.53,  = 0.01).Patient-reported outcomes: no significant differences in IKDC (WMD = 1.31,95%CI: −0.01–2.63; = 0.05) or Tegner scores (WMD: 0.01; 95% CI: -0.28– 0.30; = 0.94). Lysholm scores slightly favored reconstruction (WMD = 1.62,; 95% CI: 0.35–2.89; = 0.01).Key subgroup findings: repair achieved comparable outcomes to reconstruction in: (1) RCT-designed studies, (2) Acute repairs (< 21 days post-injury).

CONCLUSIONS

ACL repair is associated with higher failure and revision rates than reconstruction overall, but may be a viable alternative in selected patients with acute proximal tears.

SUPPLEMENTARY INFORMATION

The online version contains supplementary material available at 10.1186/s12893-025-03101-6.

摘要

背景

前交叉韧带(ACL)重建仍是金标准,但会带来供区并发症和恢复时间延长的问题。现代ACL修复技术理论上可保留天然本体感觉并实现更快的康复。我们假设现代ACL修复与重建相比将显示出非劣效的临床结果。本荟萃分析比较了初次修复与自体移植重建的临床结果。

方法

我们系统检索了PubMed、Cochrane图书馆和科学网(2015 - 2025年),以查找报告≥2项关键结果(失败率、膝关节前后向松弛度、国际膝关节文献委员会(IKDC)评分、Lysholm评分或Tegner评分)且随访≥1年的比较研究(随机对照试验、队列研究、病例对照研究)。使用RevMan 5.4计算合并的比值比(OR)和加权均数差(WMD)以及95%可信区间(CI)。进行了亚组分析(受伤至手术时间、损伤部位、研究设计、修复技术)和GRADE评估。

结果

纳入了14项研究(4项随机对照试验、8项队列研究、2项病例对照研究;n = 908例患者)(修复组:n = 460;重建组:n = 448)。失败/翻修率:与重建相比,修复显示出数值上更高的失败率(OR = 2.24,95%CI 1.30 - 3.86,P = 0.004)和翻修率(OR = 2.01,95%CI 1.21 - 3.33,P = 0.007)。取出内植物:修复组观察到取出内植物的发生率增加(OR = 8.19,95%CI 2.89 - 23.20,P < 0.001)。膝关节前后向松弛度:重建显示膝关节前后向松弛度略低(WMD = 0.30,95%CI 0.06 - 0.53,P = 0.01)。患者报告的结果:IKDC评分(WMD = 1.31,95%CI:−0.01 - 2.63;P = 0.05)或Tegner评分(WMD:0.01;95%CI: - 0.28 - 0.30;P = 0.94)无显著差异。Lysholm评分略倾向于重建(WMD = 1.62;95%CI:0.35 - 2.89;P = 0.01)。关键亚组发现:在以下情况中,修复与重建取得了可比的结果:(1)随机对照试验设计的研究,(2)急性修复(受伤后<21天)。

结论

总体而言,ACL修复与重建相比失败率和翻修率更高,但对于某些急性近端撕裂的患者可能是一种可行的替代方法。

补充信息

在线版本包含可在10.1186/s12893 - 025 - 03101 - 6获取的补充材料。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df3f/12323060/9450aac7c489/12893_2025_3101_Fig1_HTML.jpg

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