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基于国家健康保险基金数据库对2010年至2020年间匈牙利原发性震颤的患病率估计。

Prevalence estimation of essential tremor in Hungary between 2010 and 2020 based on the National Health Insurance Fund Database.

作者信息

Papp Andrea Kinga, Berki Ádám József, Vinnai Péter, Ajtay András, Bereczki Dániel, Erőss Loránd, Tamás Gertrúd

机构信息

Department of Neurology, Semmelweis University, Budapest, Hungary.

HUN-REN SU Neuroepidemiological Research Group, Budapest, Hungary.

出版信息

Sci Rep. 2025 Aug 5;15(1):28560. doi: 10.1038/s41598-025-13145-6.

Abstract

The published prevalence of essential tremor is variable worldwide and lacking in Central Europe. We aimed to estimate its prevalence in Hungary and to explore the locally applied therapeutic approaches. We collected data from the National Health Insurance Fund database and pharmacy database registered between 2010 and 2020. Matching the specified codes of the International Classification of Diseases and the individually tailored combination of interventions, we attempted to exclude Parkinson's disease and other tremor evoking conditions. We estimated the period prevalence of essential tremor age standardized to the European Standard Population at 378-388/100,000. After excluding patients with possible Parkinsonian syndromes, we found that 36.4% of patients with tremor did not take any medication during the study period. Most of the rest used alprazolam followed by propranolol for the longest period of time; the alprazolam and propranolol combination was the most preferred. Deep brain stimulation and ablative surgery were chosen for less than 0.5% of the patients. Our strict methods probably underestimate the essential tremor prevalence in Hungary, which, however, does not differ considerably from international results. Given the limitations of medication therapy, expanding and improving neurosurgical interventions may help improve the quality of life of patients with essential tremor.

摘要

原发性震颤在全球范围内公布的患病率各不相同,中欧地区尚无相关数据。我们旨在估算其在匈牙利的患病率,并探索当地应用的治疗方法。我们从2010年至2020年期间注册的国家健康保险基金数据库和药房数据库中收集数据。通过匹配国际疾病分类的特定编码以及个性化定制的干预措施组合,我们试图排除帕金森病和其他引发震颤的病症。我们估计原发性震颤的时期患病率经欧洲标准人口年龄标准化后为378 - 388/10万。在排除可能患有帕金森综合征的患者后,我们发现36.4%的震颤患者在研究期间未服用任何药物。其余大多数患者最长时间使用阿普唑仑,其次是普萘洛尔;阿普唑仑和普萘洛尔联合使用是最常用的。不到0.5%的患者选择了深部脑刺激和毁损手术。我们严格的方法可能低估了匈牙利原发性震颤的患病率,不过,这与国际结果并无太大差异。鉴于药物治疗的局限性,扩大和改进神经外科干预措施可能有助于提高原发性震颤患者的生活质量。

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