小儿肺炎管理与治疗的最新进展:全面综述
Recent updates regarding the management and treatment of pneumonia in pediatric patients: a comprehensive review.
作者信息
Ma Yan, Fan Sen, Xi JiaShui
机构信息
Department of Paediatrician, Shandong Provincial Third Hospital, Shandong, 250022, China.
Department of Paediatric Neurology, Shandong Provincial Hospital, Affiliated to Shandong First Medical University, Shandong, 250031, China.
出版信息
Infection. 2025 Aug 5. doi: 10.1007/s15010-025-02605-w.
Pneumonia remains one of the leading causes of illness and death among children, particularly in low- and middle-income countries. This review presents a comprehensive update on pediatric pneumonia, covering recent advances in etiology, clinical presentation, diagnostic tools, treatment strategies, and prevention efforts. We explore both traditional and emerging diagnostic methods, including the use of biomarkers like C-reactive protein and procalcitonin, molecular testing, and point-of-care lung ultrasound. Treatment approaches are discussed in detail, with a focus on appropriate antibiotic use, antiviral and antifungal therapies, supportive care such as oxygen therapy and fluid management, and newer interventions like high-flow nasal cannula therapy. Preventive measures, including the introduction and global rollout of pneumococcal, influenza, and RSV vaccines, are also emphasized. In addition, the review highlights ongoing challenges such as antimicrobial resistance, healthcare disparities, and the limited accessibility of advanced diagnostic tools in resource-poor settings. Finally, we outline research gaps and stress the need for strong public health policies, global collaboration, and continued innovation to reduce the burden of pediatric pneumonia and improve outcomes for children worldwide. Highlights Pediatric pneumonia continues to cause high morbidity and mortality, especially in low- and middle-income countries. Advances in diagnostics, including lung ultrasound, procalcitonin testing, and molecular tools, have improved early detection. Rational antibiotic use and stewardship programs are vital to addressing rising antimicrobial resistance. New preventive tools, such as pneumococcal, influenza, and RSV vaccines, play a key role in reducing disease burden. Health disparities and limited access to care remain major challenges, highlighting the need for policy reforms and global health initiatives.
肺炎仍然是儿童患病和死亡的主要原因之一,在低收入和中等收入国家尤其如此。本综述全面更新了小儿肺炎的相关内容,涵盖了病因、临床表现、诊断工具、治疗策略和预防措施等方面的最新进展。我们探讨了传统和新兴的诊断方法,包括使用C反应蛋白和降钙素原等生物标志物、分子检测以及即时床旁肺部超声检查。详细讨论了治疗方法,重点是合理使用抗生素、抗病毒和抗真菌治疗、支持性护理如氧疗和液体管理,以及高流量鼻导管治疗等新干预措施。还强调了预防措施,包括肺炎球菌、流感和呼吸道合胞病毒疫苗的引入和全球推广。此外,该综述突出了持续存在的挑战,如抗菌药物耐药性、医疗保健差距以及资源匮乏地区先进诊断工具的可及性有限。最后,我们概述了研究差距,并强调需要强有力的公共卫生政策、全球合作和持续创新,以减轻小儿肺炎的负担并改善全球儿童的治疗效果。要点小儿肺炎继续导致高发病率和死亡率,尤其是在低收入和中等收入国家。包括肺部超声、降钙素原检测和分子工具在内的诊断技术进步改善了早期检测。合理使用抗生素和管理计划对于应对不断上升的抗菌药物耐药性至关重要。新型预防工具,如肺炎球菌、流感和呼吸道合胞病毒疫苗,在减轻疾病负担方面发挥着关键作用。卫生差距和获得医疗服务的机会有限仍然是主要挑战,凸显了政策改革和全球卫生倡议的必要性。