Admasu Aster Tefera, Getnet Mehammed Adem, Mekonnen Chilot Kassa, Abuhay Habtamu Wagnew, Abebe Gebremeskel Kibret, Ejigu Hawltu Abiyu, Abate Hailemichael Kindie
Department of Medical Nursing, School of Nursing, College of Medicine and Health Sciences, University of Gondar, Po. Box 196, Gondar, Ethiopia.
Department of Epidemiology and Biostatistics, College of Medicine and Health Sciences, Institute of Public Health, University of Gondar, Gondar, Ethiopia.
BMC Public Health. 2025 Aug 5;25(1):2656. doi: 10.1186/s12889-025-23922-7.
People with epilepsy suffer from recurrent attacks of uncontrolled seizures and their complications. People with epilepsy have experienced uncontrolled seizures worldwide. Poorly controlled seizures result in several health consequences. Therefore, this study aimed to assess the prevalence and determinants of uncontrolled seizures among adult people with epilepsy.
A multicenter, institutional-based, cross-sectional study was conducted from April 1, 2023, to April 30, 2023. A simple random sampling technique was used to select the study participants. The data were collected by using a structured, interview-administered questionnaire and a checklist filled out by observing the patients' charts. The data was entered by using Epi data version 4.6.02 software, then exported, coded, and analyzed using the Statistical Package for Social Science (SPSS) version 25. Hosmer Lemeshow model fitness and multi-collinearity by variance inflation factor were checked. Binary logistic regression with Adjusted Odds Ratio (AOR) with 95% CI was estimated, and a P-value < 0.05 was considered statistically significant.
The overall prevalence of uncontrolled seizures was 172(42.6%). People with epilepsy who were unable to read and write [AOR = 5.13; 95% CI (1.55, 16.93)], had primary school [AOR = 5.73; 95% CI (1.89,17.42)], lived in rural residences [AOR = 1.99; 95% CI (1.03, 3.85)], had negative medication belief [AOR = 1.90; 95% CI (1.04,3.49)], take antiseizure medication for less than two years [AOR = 0.38; 95% CI (0.18,0.78)], and being farmer [AOR = 2.79; 95% CI (1.26, 6.19)], employment status [AOR = 0.13; 95% CI (0.04, 0.42)] was a significant association with uncontrolled seizure at p-value less 0.05.
In this study, the prevalence of uncontrolled seizures among adults with epilepsy was higher than in previous studies. Educational status, residence, belief in antiseizure medication, duration of antiseizure medication, occupational status, and type of seizure were significant predictors of uncontrolled seizures.
癫痫患者遭受不受控制的癫痫反复发作及其并发症的折磨。全球范围内的癫痫患者都经历过不受控制的癫痫发作。癫痫发作控制不佳会导致多种健康后果。因此，本研究旨在评估成年癫痫患者中不受控制的癫痫发作的患病率及其决定因素。
于2023年4月1日至2023年4月30日进行了一项多中心、基于机构的横断面研究。采用简单随机抽样技术选择研究参与者。通过使用结构化的访谈问卷和观察患者病历填写的清单来收集数据。数据使用Epi data 4.6.02版软件录入，然后导出、编码并使用社会科学统计软件包（SPSS）25版进行分析。检查了Hosmer Lemeshow模型拟合度和方差膨胀因子的多重共线性。估计了调整比值比（AOR）为95%置信区间（CI）的二元逻辑回归，P值<0.05被认为具有统计学意义。
不受控制的癫痫发作的总体患病率为172例（42.6%）。无法读写的癫痫患者[AOR = 5.13；95% CI（1.55，16.93）]、小学学历者[AOR = 5.73；95% CI（1.89，17.42）]、居住在农村者[AOR = 1.99；95% CI（1.03，3.85）]、对抗癫痫药物有负面信念者[AOR = 1.90；95% CI（1.04，3.49）]、服用抗癫痫药物少于两年者[AOR = 0.38；95% CI（0.18，0.78）]以及农民[AOR = 2.79；95% CI（1.26，6.19）]、就业状况[AOR = 0.13；95% CI（0.04，0.42）]与不受控制的癫痫发作在p值小于0.05时有显著关联。
在本研究中，成年癫痫患者中不受控制的癫痫发作的患病率高于先前研究。教育程度、居住情况、对抗癫痫药物的信念、抗癫痫药物的使用时长、职业状况和癫痫发作类型是不受控制的癫痫发作的重要预测因素。
