缺乏通过增强新生小鼠心肌细胞增殖促进心脏再生。
Deficiency Promotes Heart Regeneration by Enhancing Cardiomyocyte Proliferation in Neonatal Mice.
作者信息
Zou Sha, Dai Wuhou, Tao Wufan, Li Jifen, Cheng Zeyi, Wang Hongyan
机构信息
Obstetrics and Gynecology Hospital, State Key Laboratory of Genetic Engineering at School of Life Sciences, Fudan University, 200011 Shanghai, China.
Institute of Developmental Biology and Molecular Medicine, School of Life Sciences, Fudan University, 200438 Shanghai, China.
出版信息
Front Biosci (Landmark Ed). 2025 Jul 30;30(7):39676. doi: 10.31083/FBL39676.
BACKGROUND
Heart regeneration requires renewal of lost cardiomyocytes. However, the mammalian heart loses its proliferative capacity soon after birth, and the molecular signaling underlying the loss of cardiac proliferation postnatally is not fully understood.
PURPOSE
This study aimed to investigate the role of Catenin alpha 3 (), coding for alpha T catenin (αT-catenin) protein in regulating cardiomyocyte proliferation and heart regeneration during the neonatal period.
METHODS
Here we report that ablation of and highly expressed in hearts, accelerated heart regeneration following heart apex resection in neonatal mice.
RESULTS
Our results show that deficiency enhances cardiomyocyte proliferation in hearts from postnatal day 7 (P7) mice by upregulating Yes-associated protein (Yap) expression.
CONCLUSION
Our study demonstrates that deficiency is sufficient to promote heart regeneration and cardiomyocyte proliferation in neonatal mice and indicates that functional interference of α-catenins might help to stimulate myocardial regeneration after injury.
背景
心脏再生需要更新丢失的心肌细胞。然而，哺乳动物心脏在出生后不久就失去了增殖能力，产后心脏增殖丧失背后的分子信号尚未完全了解。
目的
本研究旨在探讨编码αT连环蛋白（αT-catenin）的连环蛋白α3（）在调节新生期心肌细胞增殖和心脏再生中的作用。
方法
在此我们报告，在心脏中高度表达的的缺失，加速了新生小鼠心尖切除术后的心脏再生。
结果
我们的结果表明，缺失通过上调Yes相关蛋白（Yap）的表达增强了出生后第7天（P7）小鼠心脏中的心肌细胞增殖。
结论
我们的研究表明，缺失足以促进新生小鼠的心脏再生和心肌细胞增殖，并表明α连环蛋白的功能干扰可能有助于刺激损伤后的心肌再生。
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