Richa J, Damsky C H, Buck C A, Knowles B B, Solter D
Dev Biol. 1985 Apr;108(2):513-21. doi: 10.1016/0012-1606(85)90054-5.
Early mouse embryos undergo several morphogenetic processes, such as compaction, trophoblast attachment, and endoderm formation that can be studied in vitro. Several polyspecific and monospecific antisera have been used to perturb these processes in a nontoxic, reversible fashion. One of the antibody-defined molecules, cell CAM 120/80, promotes epithelial cell adhesion, embryo compaction, and endoderm formation. The results suggest the presence of another such molecule(s) involved in these same processes. Evidence is also presented that another set of antibody-defined molecules, GP 140, involved in attachment of somatic cells to the substrate, mediates trophoblast attachment of the mouse blastocyst. The possible role of these molecules in governing the processes leading to cell lineages in the mouse embryo is discussed.
早期小鼠胚胎会经历多种形态发生过程，如致密化、滋养层附着和内胚层形成，这些过程可以在体外进行研究。几种多特异性和单特异性抗血清已被用于以无毒、可逆的方式干扰这些过程。一种由抗体定义的分子，细胞黏附分子120/80，可促进上皮细胞黏附、胚胎致密化和内胚层形成。结果表明存在另一种参与这些相同过程的此类分子。还有证据表明，另一组由抗体定义的分子，GP 140，参与体细胞与底物的附着，介导小鼠囊胚的滋养层附着。本文讨论了这些分子在控制小鼠胚胎细胞谱系形成过程中可能发挥的作用。
